2. Gene
  3. Kl - klotho Gene

Kl - klotho Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: alpha-kl

基因 ID: 16591 | 基因类型: protein coding

关于 Kl

功能概要

Enables Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Acts upstream of or within several processes, including calcium ion homeostasis; energy reserve metabolic process; and positive regulation of MAPKKK cascade by Fibroblast Growth Factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Is expressed in brain. Used to study hyperphosphatemic familial tumoral calcinosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]

Kl 基因产物(1)

mRNA Protein Name
NM_013823.2 NP_038851.2 klotho precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibroblast growth factor binding IPI
IPI: 通过物理相互作用推断
17086194 MGI
enables fibroblast growth factor receptor binding IPI
IPI: 通过物理相互作用推断
17086194 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16436388 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcium ion homeostasis IGI
IGI: 通过遗传相互作用推断
22285620 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: 通过突变表型推断
9363890 MGI
acts upstream of or within energy reserve metabolic process IMP
IMP: 通过突变表型推断
11095966 MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
16436388 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

klotho

secreted form of Klotho protein

重组 Kl 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72879 CD117/c-Kit Protein, Mouse (HEK293, Fc) P05532 (S25-T523) ≥95%

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13204 Biperiden hydrochloride Inhibitor 99.90% 否
HY-13204A Biperiden Inhibitor 99.74% 否
HY-13204B Biperiden lactate Inhibitor / 否
HY-13204R Biperiden hydrochloride (Standard) Inhibitor / 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-108468 KL001 99.68% Phase 1
HY-19842 GS-9667 Agonist 98.08% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99544 Tagitanlimab Inhibitor ≥99.0% Phase 3
Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145597 KL-11743 99.40% 否
HY-D0286 Fluorol Yellow 088 ≥98.0% 否
HY-123972 SEC inhibitor KL-2 Inhibitor 99.49% 否
HY-122720 SEC inhibitor KL-1 Activator 99.58% 否
HY-128895 KL1333 99.94% 否
HY-148185 T01-1 99.87% 否
HY-119506 KL044 99.05% 否
HY-134194 KL201 98.18% 否
HY-172825 KL4-219A Degrader 99.85% 否
HY-164496 KL-50 Inhibitor 99.82% 否
HY-121849 KL-1156 Inhibitor / 否
HY-128895A KL1333 hydrochloride Modulator / 否
HY-13204S Biperiden-d5 hydrochloride Inhibitor / 否
HY-13204S1 rel-Biperiden-d5 Inhibitor / 否
HY-13204S2 rel-Biperiden EP impurity A-d5 Inhibitor / 否
HY-13204S3 rel-Biperiden EP impurity B-d5 Inhibitor / 否
HY-143969S KL140061A-d4 / 否
HY-155972 CRM1-IN-1 Inhibitor / 否
HY-155972A CRM1-IN-2 / 否
HY-169086 KL-465 / 否
HY-RS07324 KL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10569 PIP5KL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-13204AS Biperiden-d5 Inhibitor / 否
HY-174774 Human BMPR1B mRNA / 否
HY-RS17481 Kl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23939 Kl Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991302 KL-A289 Inhibitor / 否
HY-P990184 Anti-Mouse MHC Class II (βchain) Antibody (KL277) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kl NCBI NCBI:9365
Macaca fascicularis Kl NCBI NCBI:102115572
Rattus norvegicus Kl NCBI NCBI:83504
Macaca mulatta Kl NCBI NCBI:714042
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