2. Gene
  3. Kl - Klotho Gene

Kl - Klotho Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 83504 | 基因类型: protein coding

关于 Kl

功能概要

Predicted to enable Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in membrane. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]

Kl 基因产物(1)

mRNA Protein Name
NM_031336.2 NP_112626.1 klotho precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
20086041 RGD
involved in norepinephrine biosynthetic process IMP
IMP: 通过突变表型推断
20086041 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
22891896 RGD
involved in response to angiotensin IEP
IEP: 通过表达模式推断
11967236 RGD
involved in response to fibroblast growth factor IEP
IEP: 通过表达模式推断
17992255 RGD
involved in response to vitamin D IEP
IEP: 通过表达模式推断
20631679 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

klotho

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13204 Biperiden hydrochloride Inhibitor 99.90% 否
HY-13204A Biperiden Inhibitor 99.74% 否
HY-13204B Biperiden lactate Inhibitor / 否
HY-13204R Biperiden hydrochloride (Standard) Inhibitor / 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-108468 KL001 99.68% Phase 1
HY-19842 GS-9667 Agonist 98.08% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99544 Tagitanlimab Inhibitor ≥99.0% Phase 3
Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145597 KL-11743 99.40% 否
HY-D0286 Fluorol Yellow 088 ≥98.0% 否
HY-123972 SEC inhibitor KL-2 Inhibitor 99.49% 否
HY-122720 SEC inhibitor KL-1 Activator 99.58% 否
HY-128895 KL1333 99.94% 否
HY-148185 T01-1 99.87% 否
HY-119506 KL044 99.05% 否
HY-134194 KL201 98.18% 否
HY-172825 KL4-219A Degrader 99.85% 否
HY-164496 KL-50 Inhibitor 99.82% 否
HY-121849 KL-1156 Inhibitor / 否
HY-128895A KL1333 hydrochloride Modulator / 否
HY-13204S Biperiden-d5 hydrochloride Inhibitor / 否
HY-13204S1 rel-Biperiden-d5 Inhibitor / 否
HY-13204S2 rel-Biperiden EP impurity A-d5 Inhibitor / 否
HY-13204S3 rel-Biperiden EP impurity B-d5 Inhibitor / 否
HY-143969S KL140061A-d4 / 否
HY-155972 CRM1-IN-1 Inhibitor / 否
HY-155972A CRM1-IN-2 / 否
HY-169086 KL-465 / 否
HY-RS07324 KL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10569 PIP5KL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-13204AS Biperiden-d5 Inhibitor / 否
HY-174774 Human BMPR1B mRNA / 否
HY-RS17481 Kl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23939 Kl Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991302 KL-A289 Inhibitor / 否
HY-P990184 Anti-Mouse MHC Class II (βchain) Antibody (KL277) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kl NCBI NCBI:9365
Macaca fascicularis Kl NCBI NCBI:102115572
Mus musculus Kl NCBI NCBI:16591
Macaca mulatta Kl NCBI NCBI:714042
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