2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Biperiden hydrochloride

Biperiden hydrochloride  (Synonyms: 盐酸比哌立登; KL 373 hydrochloride)

目录号: HY-13204
COA 产品使用指南

摩尔计算器

Biperiden (KL 373) hydrochloride 是一种非选择性毒蕈碱受体 (muscarinic receptor) 拮抗剂，可以与 M1 毒蕈碱受体竞争性结合，从而抑制乙酰胆碱 (acetylcholine) 并增强中枢神经系统中多巴胺信号传导。 Biperiden hydrochloride 可用于帕金森病以及其他相关精神疾病的研究。

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Biperiden hydrochloride Chemical Structure

Biperiden hydrochloride Chemical Structure

CAS No. : 1235-82-1

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规格 价格 是否有货
10 mM * 1 mL in DMSO ￥1100
询问价格 & 货期
5 mg ￥1000
询问价格 & 货期
10 mg ￥1600
询问价格 & 货期

* Please select Quantity before adding items.

Biperiden hydrochloride 的其他形式现货产品:

Other Forms of Biperiden hydrochloride:

Biperiden hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].

体外研究
(In Vitro)

Biperiden hydrochloride (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biperiden hydrochloride 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration: 29.6 μg/mL
Incubation Time: 72 hours
Result: Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.
体内研究
(In Vivo)

Biperiden hydrochloride (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1].
Biperiden hydrochloride (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; everyday; 3 weeks
Result: Tumor size reduced by 83%.
Animal Model: Male Wistar rats (200-250 g)[2]
Dosage: 8 mg/kg
Administration: Intraperitoneal injection; every 8 hours; 10 days
Result: Reduced late seizures by about three times with no affecting emotional memory damage.
Clinical Trial
分子量

347.92

Formula

C21H30ClNO
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸比哌立登；双环哌丙醇盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 20 mg/mL (57.48 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 5 mg/mL (14.37 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8742 mL 14.3711 mL 28.7422 mL
5 mM 0.5748 mL 2.8742 mL 5.7484 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Biperiden hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.8742 mL 14.3711 mL 28.7422 mL 71.8556 mL
5 mM 0.5748 mL 2.8742 mL 5.7484 mL 14.3711 mL
10 mM 0.2874 mL 1.4371 mL 2.8742 mL 7.1856 mL
DMSO 15 mM 0.1916 mL 0.9581 mL 1.9161 mL 4.7904 mL
20 mM 0.1437 mL 0.7186 mL 1.4371 mL 3.5928 mL
25 mM 0.1150 mL 0.5748 mL 1.1497 mL 2.8742 mL
30 mM 0.0958 mL 0.4790 mL 0.9581 mL 2.3952 mL
40 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.7964 mL
50 mM 0.0575 mL 0.2874 mL 0.5748 mL 1.4371 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biperiden1235-82-1KL 373盐酸比哌立登双环哌丙醇盐酸盐KL373KL-373mAChRMuscarinic acetylcholine receptorMuscarinic receptor antagonistParkinson's diseaseAnticholinergicInhibitorinhibitorinhibit

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目录号：
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