1. Others
  2. Others
  3. SEC inhibitor KL-1

SEC inhibitor KL-1 (Synonyms: KL-1)

目录号: HY-122720
产品使用指南

SEC inhibitor KL-1 (KL-1) 是一种拟肽先导化合物,有效的选择性 SEC 抑制剂,通过破坏 SEC 支架蛋白 AFF4 和 P-TEFb 之间的相互作用,导致 Pol II 从启动子近端暂停位点的释放受损并且进行性转录延伸的平均速率降低。SEC inhibitor KL-1 剂量依赖性地抑制 AFF4-CCNT1 相互作用,Ki 值为 3.48 μM。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

SEC inhibitor KL-1 Chemical Structure

SEC inhibitor KL-1 Chemical Structure

CAS No. : 900308-84-1

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
1 mg   Get quote  
5 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].

IC50 & Target

SEC[1]

Molecular Weight

345.78

Formula

C₁₈H₁₆ClNO₄

CAS No.

900308-84-1

SMILES

O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=CC(OC)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
SEC inhibitor KL-1
目录号:
HY-122720
需求量:

SEC inhibitor KL-1

Cat. No.: HY-122720