2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. T01-1

T01-1 是一种抗癌剂 (喜树碱衍生物)，具有较好的抗肿瘤细胞增殖活性。

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T01-1 Chemical Structure

T01-1 Chemical Structure

CAS No. : 2356229-14-4

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规格 价格 是否有货 数量
50 mg ￥8800
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Customer Review

T01-1 相关抗体

Top Publications Citing Use of Products

查看 ADC Cytotoxin 亚型特异性产品:

查看所有亚型
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].

体外研究
(In Vitro)

T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

T01-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCC1806 cells
Concentration: 0-50 nM
Incubation Time: 3 days
Result: Inhibited cell proliferation with an EC50 value of 6.7 nM.
体内研究
(In Vivo)

T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rat (half male and half female)[1].
Dosage: 1 mg/kg
Administration: Intravenous injection; single
Result: 1.19 Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat [1].
IV (1 mg/kg)
Female Male
AUCLast (ng/mL•h) 437 214
Cmax (ng/mL) 838 625
MRTINF (h) 2.81 0.44
T1/2 (h) 2.78 1.97
Tmax (h) 0.08 0.08
分子量

511.59

Formula

C26H29N3O6S
CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

T01-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T01-12356229-14-4ADC CytotoxinADC PayloadHCC1806camptothecin derivativecancertumourantiproliferativeInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
T01-1
目录号：
HY-148185
需求量：

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