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SEC inhibitor KL-2 (Synonyms: KL-2)

目录号: HY-123972 纯度: >99.0%
产品使用指南

SEC inhibitor KL-2 (KL-2) 是一种拟肽先导化合物,有效的选择性 SEC 抑制剂,通过破坏 SEC 支架蛋白 AFF4 和 P-TEFb 之间的相互作用,导致 Pol II 从启动子近端暂停位点的释放受损并且进行性转录延伸的平均速率降低。SEC inhibitor KL-2 剂量依赖性地抑制 AFF4-CCNT1 相互作用,Ki 值为 1.50 μM。

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SEC inhibitor KL-2 Chemical Structure

SEC inhibitor KL-2 Chemical Structure

CAS No. : 900308-51-2

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Description

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].

IC50 & Target

SEC[1]

Molecular Weight

333.74

Formula

C₁₇H₁₃ClFNO₃

CAS No.

900308-51-2

SMILES

O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=C(F)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

SEC inhibitor KL-2KL-2SEC inhibitor KL2SEC inhibitor KL 2KL2KL 2OthersInhibitorinhibitorinhibit

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产品名称:
SEC inhibitor KL-2
目录号:
HY-123972
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