Lipa - lysosomal acid lipase A Gene

种属: Mus musculus

同用名: Lal; Lip1; Lip-1

基因 ID: 16889 | 基因类型: protein coding

关于 Lipa

功能概要

Predicted to enable sterol esterase activity. Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; lung development; and tissue remodeling. Predicted to be located in cytosol; lysosome; and nuclear lumen. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal cortex zone; alimentary system; brain; hemolymphoid system; and metanephros. Used to study Wolman disease and lysosomal and Lipase deficiency. Human ortholog(s) of this gene implicated in Wolman disease; Cholesterol ester storage disease; and lysosomal and Lipase deficiency. Orthologous to human LIPA (Lipase A, lysosomal acid type). [provided by Alliance of Genome Resources, Apr 2022]

Lipa 基因产物(2)

mRNA	Protein	Name
NM_001111100.1	NP_001104570.1	lysosomal acid lipase/cholesteryl ester hydrolase precursor
NM_021460.3	NP_067435.3	lysosomal acid lipase/cholesteryl ester hydrolase precursor

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within ATP biosynthetic process	IMP IMP: 通过突变表型推断	24287405	MGI
acts upstream of or within T cell apoptotic process	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within T cell differentiation	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within T cell proliferation	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within TOR signaling	IMP IMP: 通过突变表型推断	22383970	MGI
acts upstream of or within acute inflammatory response	IMP IMP: 通过突变表型推断	28402950	MGI
acts upstream of or within adaptive thermogenesis	IMP IMP: 通过突变表型推断	29374543	MGI
acts upstream of or within adipose tissue development	IMP IMP: 通过突变表型推断	29374543	MGI
acts upstream of or within blood vessel endothelial cell differentiation	IMP IMP: 通过突变表型推断	33357458	MGI
acts upstream of or within bone marrow development	IMP IMP: 通过突变表型推断	20348241	MGI
acts upstream of or within cell morphogenesis	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within cell population proliferation	IMP IMP: 通过突变表型推断	22383970	MGI
acts upstream of or within cell proliferation in bone marrow	IMP IMP: 通过突变表型推断	20348241	MGI
acts upstream of or within cellular lipid biosynthetic process	IMP IMP: 通过突变表型推断	28402950	MGI
acts upstream of or within cellular lipid metabolic process	IMP IMP: 通过突变表型推断	28402950	MGI
acts upstream of or within cholesterol biosynthetic process	IMP IMP: 通过突变表型推断	25147230	MGI
acts upstream of or within cholesterol efflux	IMP IMP: 通过突变表型推断	29599133	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: 通过突变表型推断	24370824	MGI
acts upstream of or within cholesterol storage	IGI IGI: 通过遗传相互作用推断	25450374	MGI
acts upstream of or within cholesterol storage	IMP IMP: 通过突变表型推断	24370824	MGI
acts upstream of or within cholesterol transport	IMP IMP: 通过突变表型推断	29599133	MGI
acts upstream of or within common myeloid progenitor cell proliferation	IMP IMP: 通过突变表型推断	24287405	MGI
acts upstream of or within cytokine production	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within defecation	IMP IMP: 通过突变表型推断	25147230	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: 通过突变表型推断	25147230	MGI
acts upstream of or within endocytosis	IMP IMP: 通过突变表型推断	33357458	MGI
acts upstream of or within endosome to lysosome transport	IMP IMP: 通过突变表型推断	33357458	MGI
acts upstream of or within endothelial cell proliferation	IMP IMP: 通过突变表型推断	33357458	MGI
acts upstream of or within energy homeostasis	IMP IMP: 通过突变表型推断	30639734	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within fat cell proliferation	IMP IMP: 通过突变表型推断	33357458	MGI
acts upstream of or within fatty acid metabolic process	IMP IMP: 通过突变表型推断	29374543	MGI
acts upstream of or within gene expression	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within glucose metabolic process	IMP IMP: 通过突变表型推断	30639734	MGI
acts upstream of or within glycolytic process	IMP IMP: 通过突变表型推断	25807535	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: 通过突变表型推断	20348241	MGI
acts upstream of or within hemopoiesis	IMP IMP: 通过突变表型推断	20348241	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: 通过突变表型推断	33159889	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within inflammatory response	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within lipid homeostasis	IMP IMP: 通过突变表型推断	30639734	MGI
acts upstream of or within lipid import into cell	IMP IMP: 通过突变表型推断	29374543	MGI
acts upstream of or within lipid metabolic process	IMP IMP: 通过突变表型推断	25147230	MGI
acts upstream of or within lipid storage	IMP IMP: 通过突变表型推断	31023823	MGI
acts upstream of or within lipoprotein catabolic process	IMP IMP: 通过突变表型推断	33357458	MGI
acts upstream of or within liver development	IMP IMP: 通过突变表型推断	24370824	MGI
acts upstream of or within liver morphogenesis	IMP IMP: 通过突变表型推断	24370824	MGI
acts upstream of or within lung development	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within lysosome organization	IMP IMP: 通过突变表型推断	25807535	MGI
acts upstream of or within macrophage homeostasis	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within mitochondrion organization	IMP IMP: 通过突变表型推断	25807535	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: 通过突变表型推断	22383970	MGI
acts upstream of or within multicellular organismal-level chemical homeostasis	IMP IMP: 通过突变表型推断	27354281	MGI
acts upstream of or within multicellular organismal-level homeostasis	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within myeloid cell apoptotic process	IMP IMP: 通过突变表型推断	20348241	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: 通过突变表型推断	20348241	MGI
acts upstream of or within neutral lipid metabolic process	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within positive regulation of T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within programmed cell death	IMP IMP: 通过突变表型推断	21697390	MGI
acts upstream of or within reactive oxygen species biosynthetic process	IMP IMP: 通过突变表型推断	24287405	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: 通过突变表型推断	25807535	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: 通过突变表型推断	24287405	MGI
acts upstream of or within respiratory burst involved in inflammatory response	IMP IMP: 通过突变表型推断	25807535	MGI
acts upstream of or within response to cold	IMP IMP: 通过突变表型推断	29374543	MGI
acts upstream of or within response to dietary excess	IMP IMP: 通过突变表型推断	30639734	MGI
acts upstream of or within response to lipid	IMP IMP: 通过突变表型推断	29599133	MGI
acts upstream of or within response to rapamycin	IMP IMP: 通过突变表型推断	25807535	MGI
acts upstream of or within response to vitamin A	IMP IMP: 通过突变表型推断	31023823	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: 通过突变表型推断	24370824	MGI
acts upstream of or within retinoid metabolic process	IMP IMP: 通过突变表型推断	27354281	MGI
acts upstream of or within small GTPase-mediated signal transduction	IMP IMP: 通过突变表型推断	22383970	MGI
acts upstream of or within spleen development	IMP IMP: 通过突变表型推断	19179613	MGI
acts upstream of or within sterol metabolic process	IMP IMP: 通过突变表型推断	21289032	MGI
acts upstream of or within tissue remodeling	IMP IMP: 通过突变表型推断	14644759	MGI
acts upstream of or within triglyceride metabolic process	IMP IMP: 通过突变表型推断	30639734	MGI
acts upstream of or within triglyceride-rich lipoprotein particle clearance	IMP IMP: 通过突变表型推断	33357458	MGI
acts upstream of or within vitamin A metabolic process	IMP IMP: 通过突变表型推断	27354281	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in lysosome	IDA IDA: 通过直接分析推断	21289032	MGI
is active in lysosome	IMP IMP: 通过突变表型推断	28402950	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

lysosomal acid lipase/cholesteryl ester hydrolase

acid cholesteryl ester hydrolase	cholesteryl esterase
lipase A	lysosomal acid lipase 1
sterol esterase

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148755	ERX-41		98.25%	否
HY-RS17291	Lipa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS02454	CEL Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS07684	LIPA Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23746	Lipa Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Lipa	NCBI	NCBI:3988
Canis lupus familiaris	Lipa	NCBI
Rattus norvegicus	Lipa	NCBI	NCBI:25055

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Lipa - lysosomal acid lipase A Gene

关于 Lipa

功能概要

Lipa 基因产物(2)

直系同源

热门区域

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Lipa - lysosomal acid lipase A Gene

关于 Lipa

功能概要

Lipa 基因产物(2)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z