2. Gene
  3. ADAMTS16 - ADAM metallopeptidase with thrombospondin type 1 motif 16 Gene

ADAMTS16 - ADAM metallopeptidase with thrombospondin type 1 motif 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有 1 型血小板反应蛋白基序的 ADAM 金属肽酶 16

种属: Homo sapiens

同用名: ADAMTS16s

基因 ID: 170690 | 基因类型: protein coding

关于 ADAMTS16

Cytogenetic location: 5p15.32 Genomic coordinates (GRCh38): 5:5,140,330-5,320,304 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 25 paralogues. Biased expression in ovary (RPKM 5.4), gall bladder (RPKM 4.3) and 8 other tissues.

功能概要

该基因编码 ADAMTS (一种具有血小板反应蛋白基序的去整合素和金属蛋白酶) 蛋白家族的成员。 ADAMTS 家族成员共享几个不同的蛋白质模块，包括前肽区域、金属蛋白酶结构域、解整合素样结构域和 1 型血小板反应蛋白 (TS) 基序。这个家族的个别成员在 C 端 TS 基序的数量上有所不同，有些成员具有独特的 C 端结构域。编码的前原蛋白经过蛋白水解处理，生成成熟蛋白，可抑制软骨肉瘤细胞增殖和迁移。该基因可以调节血压。[RefSeq 提供，2016 年 5 月]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]

ADAMTS16 基因产物(1)

mRNA Protein Name
NM_139056.4 NP_620687.2 A disintegrin and metalloproteinase with thrombospondin motifs 16 preproprotein

ADAMTS16 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (60 - 205)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (292 - 495)

TSP_1

TSP_1: Thrombospondin type 1 domain (590 - 640)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (748 - 858)

TSP_1

TSP_1: Thrombospondin type 1 domain (934 - 986)

TSP_1

TSP_1: Thrombospondin type 1 domain (993 - 1031)

TSP_1

TSP_1: Thrombospondin type 1 domain (1058 - 1081)

TSP_1

TSP_1: Thrombospondin type 1 domain (1133 - 1169)

PLAC

PLAC: PLAC (protease and lacunin) domain (1190 - 1221)

  • 0
  • 200
  • 400
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  • 800
  • 1000
  • 1224 a.a.
蛋白主名 其他名称

A disintegrin and metalloproteinase with thrombospondin motifs 16

ADAM-TS 16

关联疾病

疾病名称 别名
Weill-Marchesani Syndrome

Gemss Syndrome

Spherophakia-Brachymorphia Syndrome

Marchesani-Weill Syndrome

Wms

Congenital Mesodermal Dystrophy

Mesodermal Dysmorphodystrophy, Congenital

Spherophakia Brachymorphia Syndrome

Mesodermal Dysmorphodystrophy Congenital

Wm Syndrome

Brachydactyly-Spherophakia Syndrome

Brachymorphy With Spherophakia Syndrome

Congenital Mesodermal Dysmorphodystrophy

Marchesani Syndrome

Weill-Marchesani Syndrome, Autosomal Recessive

Weill-Marchesani Syndrome, Autosomal Dominant
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00297 ADAMTS16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ADAMTS16 VGNC VGNC:59590
Canis familiaris ADAMTS16 VGNC VGNC:37594
Bos taurus ADAMTS16 VGNC VGNC:25620
Macaca mulatta ADAMTS16 VGNC VGNC:69439
Rattus norvegicus ADAMTS16 RGD RGD:1310046
Mus musculus ADAMTS16 MGD MGI:2429637
Others ADAMTS16 NCBI
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