1. Gene
  2. KCNG3 - potassium voltage-gated channel modifier subfamily G member 3 Gene

KCNG3 - potassium voltage-gated channel modifier subfamily G member 3 Gene

中文名称:钾电压门控通道调节因子亚科 G 成员 3

种属: Homo sapiens

同用名: KV6.3; KV10.1

基因 ID: 170850 | 基因类型: protein coding

关于 KCNG3

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,388,352-42,493,982 (from NCBI)

This gene has 2 transcripts (splice variants), 182 orthologues and 31 paralogues. Low expression observed in reference dataset.

功能概要

从功能和结构的角度来看,电压门控钾 (Kv) 通道代表了最复杂的一类电压门控离子通道。它们的不同功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。该基因编码钾通道电压门控 G 亚科的一个成员。该成员是一个作为调节分子发挥作用的 γ 亚基。可变剪接导致编码不同亚型的两个转录本变体。[RefSeq 提供,2008 年 7 月]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

KCNG3 基因产物(2)

mRNA Protein Name
NM_133329.6 NP_579875.1 potassium voltage-gated channel subfamily G member 3 isoform 1
NM_172344.3 NP_758847.1 potassium voltage-gated channel subfamily G member 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables potassium channel regulator activity IDA
IDA: 通过直接分析推断
11852086 GOA
enables potassium channel regulator activity IGI
IGI: 通过遗传相互作用推断
15046870 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11852086 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
19074135 GOA
involved in regulation of potassium ion transport IDA
IDA: 通过直接分析推断
11852086 GOA
acts upstream of or within regulation of potassium ion transport IGI
IGI: 通过遗传相互作用推断
15046870 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12060745 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12060745 GOA
part of voltage-gated potassium channel complex IDA
IDA: 通过直接分析推断
19074135 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KCNG3 蛋白结构

BTB_2

BTB_2: BTB/POZ domain (11 - 111)

Ion_trans

Ion_trans: Ion transport protein (223 - 408)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
蛋白主名 其他名称

potassium voltage-gated channel subfamily G member 3

potassium channel, voltage gated modifier subfamily G, member 3

关联疾病

疾病名称 别名
Retinal Cone Dystrophy 3b

RCD3B

Cone Dystrophy With Supernormal Rod Response

Cone Dystrophy With Supernormal Rod Electroretinogram

Cone Dystrophy With Supernormal Rod Responses

Cdsrr

Cone Dystrophy With Night Blindness And Supernormal Rod Responses, Kcnv2-Related

Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2 Related

Cone Dystrophy With Supernormal Rod Erg

Cone Dystrophy With Supernormal Scotopic Electroretinogram

Cone Dystrophy Retinal 3b

Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2-Related

Doid:0081022

Dystrophy, Retinal Cone, Type 3b

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KCNG3 VGNC VGNC:42246
Rattus norvegicus KCNG3 RGD RGD:628832
Bos taurus KCNG3 VGNC VGNC:58383
Macaca mulatta KCNG3 VGNC VGNC:106175
Mus musculus KCNG3 MGD MGI:2663923