2. Gene
  3. Nlgn3 - neuroligin 3 Gene

Nlgn3 - neuroligin 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 171297 | 基因类型: protein coding

关于 Nlgn3

功能概要

Enables cell adhesion molecule binding activity; neurexin family protein binding activity; and signaling receptor activity. Involved in several processes, including inhibitory postsynaptic potential; neuron cell-cell adhesion; and synapse assembly. Acts upstream of or within synapse organization. Located in several cellular components, including cell surface; endocytic vesicle; and neuronal cell body. Is integral component of postsynaptic membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Colocalizes with dendrite; excitatory synapse; and inhibitory synapse. Used to study autism spectrum disorder. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn3 基因产物(1)

mRNA Protein Name
NM_134336.2 NP_599163.2 neuroligin-3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell adhesion molecule binding IPI
IPI: 通过物理相互作用推断
15152050 RGD
enables neurexin family protein binding IPI
IPI: 通过物理相互作用推断
15152050 RGD
enables signaling receptor activity IDA
IDA: 通过直接分析推断
15797875 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon extension IMP
IMP: 通过突变表型推断
19406211 RGD
involved in circadian sleep/wake cycle IMP
IMP: 通过突变表型推断
28958035 RGD
involved in inhibitory postsynaptic potential IDA
IDA: 通过直接分析推断
19406211 RGD
involved in neuron cell-cell adhesion IDA
IDA: 通过直接分析推断
15797875 RGD
involved in positive regulation of dendritic spine development IMP
IMP: 通过突变表型推断
15681343 RGD
involved in positive regulation of inhibitory postsynaptic potential IDA
IDA: 通过直接分析推断
19406211 RGD
involved in positive regulation of protein localization to synapse IMP
IMP: 通过突变表型推断
15681343 RGD
involved in positive regulation of synapse assembly IDA
IDA: 通过直接分析推断
15797875 RGD
involved in postsynaptic specialization assembly IDA
IDA: 通过直接分析推断
17897391 RGD
involved in prepulse inhibition IMP
IMP: 通过突变表型推断
28958035 RGD
involved in presynaptic membrane assembly IDA
IDA: 通过直接分析推断
15797875 RGD
involved in receptor-mediated endocytosis IDA
IDA: 通过直接分析推断
15797875 RGD
involved in rhythmic synaptic transmission IMP
IMP: 通过突变表型推断
19406211 RGD
involved in synapse assembly IDA
IDA: 通过直接分析推断
15797875 RGD
acts upstream of or within synapse organization IDA
IDA: 通过直接分析推断
15681343 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
17897391 RGD
located in cell surface IDA
IDA: 通过直接分析推断
15797875 RGD
located in dendrite IDA
IDA: 通过直接分析推断
17897391 RGD
located in endocytic vesicle IDA
IDA: 通过直接分析推断
15797875 RGD
located in excitatory synapse IDA
IDA: 通过直接分析推断
17897391 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17897391 RGD
located in inhibitory synapse IDA
IDA: 通过直接分析推断
17897391 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
17897391 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
15797875 RGD
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
17897391 RGD
located in synapse IDA
IDA: 通过直接分析推断
15681343 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neuroligin-3

gliotactin homolog

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09341 NLGN3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18397 Nlgn3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24879 Nlgn3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nlgn3 NCBI NCBI:54413
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