2. Gene
  3. Ascl1 - achaete-scute family bHLH transcription factor 1 Gene

Ascl1 - achaete-scute family bHLH transcription factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ASH1; Mash1; bHLHa46

基因 ID: 17172 | 基因类型: protein coding

关于 Ascl1

功能概要

Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in nervous system development. Acts upstream of or within several processes, including musculoskeletal movement, spinal reflex action; nervous system development; and neuroendocrine cell differentiation. Located in neuronal cell body and nucleus. Is expressed in several structures, including future brain; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ascl1 基因产物(1)

mRNA Protein Name
NM_008553.5 NP_032579.2 achaete-scute homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
17141158 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
23639443 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23639443 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17141158 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within GABAergic neuron differentiation IGI
IGI: 通过遗传相互作用推断
15071116 MGI
acts upstream of or within Notch signaling pathway IGI
IGI: 通过遗传相互作用推断
15976074 MGI
acts upstream of Notch signaling pathway IMP
IMP: 通过突变表型推断
11073877 MGI
acts upstream of or within adrenal chromaffin cell differentiation IMP
IMP: 通过突变表型推断
12361965 MGI
acts upstream of or within carotid body glomus cell differentiation IMP
IMP: 通过突变表型推断
15878769 MGI
acts upstream of or within cell maturation IMP
IMP: 通过突变表型推断
16766700 MGI
acts upstream of or within central nervous system neuron development IGI
IGI: 通过遗传相互作用推断
15169849 MGI
acts upstream of or within central nervous system neuron development IMP
IMP: 通过突变表型推断
16469766 MGI
acts upstream of or within cerebral cortex development IMP
IMP: 通过突变表型推断
17678855 MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain IMP
IMP: 通过突变表型推断
22991444 MGI
acts upstream of or within generation of neurons IMP
IMP: 通过突变表型推断
23616538 MGI
acts upstream of or within lung neuroendocrine cell differentiation IMP
IMP: 通过突变表型推断
9126746 MGI
acts upstream of or within motor neuron migration IGI
IGI: 通过遗传相互作用推断
15976074 MGI
acts upstream of or within motor neuron migration IMP
IMP: 通过突变表型推断
15976074 MGI
acts upstream of or within musculoskeletal movement, spinal reflex action IMP
IMP: 通过突变表型推断
23616538 MGI
involved in nervous system development IDA
IDA: 通过直接分析推断
24243019 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
21536733 MGI
acts upstream of or within neuroblast fate determination IMP
IMP: 通过突变表型推断
11032813 MGI
acts upstream of or within neuroblast proliferation IGI
IGI: 通过遗传相互作用推断
15976074 MGI
acts upstream of or within neuroendocrine cell differentiation IMP
IMP: 通过突变表型推断
10952889 MGI
involved in neuron development IDA
IDA: 通过直接分析推断
24243019 MGI
acts upstream of or within neuron development IMP
IMP: 通过突变表型推断
9108377 MGI
acts upstream of or within neuron differentiation IDA
IDA: 通过直接分析推断
18184563 MGI
involved in neuron differentiation IDA
IDA: 通过直接分析推断
24243019 MGI
acts upstream of or within neuron differentiation IMP
IMP: 通过突变表型推断
15133515 MGI
involved in neuron fate commitment IDA
IDA: 通过直接分析推断
24243019 MGI
acts upstream of or within neuron fate commitment IGI
IGI: 通过遗传相互作用推断
16020526 MGI
acts upstream of or within neuron fate commitment IMP
IMP: 通过突变表型推断
12629181 MGI
involved in neuron fate specification IDA
IDA: 通过直接分析推断
24243019 MGI
acts upstream of or within neuron fate specification IMP
IMP: 通过突变表型推断
16469766 MGI
involved in noradrenergic neuron development IMP
IMP: 通过突变表型推断
18094025 MGI
acts upstream of or within olfactory pit development IMP
IMP: 通过突变表型推断
9108377 MGI
acts upstream of or within oligodendrocyte cell fate commitment IMP
IMP: 通过突变表型推断
17678855 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: 通过突变表型推断
18287202 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: 通过遗传相互作用推断
15976074 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
18287202 MGI
acts upstream of or within pattern specification process IMP
IMP: 通过突变表型推断
15930101 MGI
acts upstream of or within peripheral nervous system neuron development IMP
IMP: 通过突变表型推断
8845150 MGI
acts upstream of or within positive regulation of Notch signaling pathway IMP
IMP: 通过突变表型推断
11073877 MGI
acts upstream of or within positive regulation of cell cycle IDA
IDA: 通过直接分析推断
21536733 MGI
acts upstream of or within positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
21536733 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: 通过突变表型推断
16469766 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
16469766 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17141158 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
8900141 MGI
acts upstream of or within regulation of Notch signaling pathway IMP
IMP: 通过突变表型推断
19191219 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: 通过直接分析推断
19793887 MGI
acts upstream of or within regulation of epithelial cell differentiation IMP
IMP: 通过突变表型推断
23284756 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
16469766 MGI
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
18094025 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
22991444 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: 通过突变表型推断
20144606 MGI
acts upstream of or within regulation of timing of subpallium neuron differentiation IMP
IMP: 通过突变表型推断
9876181 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19796622 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
24243019 MGI
acts upstream of or within spinal cord association neuron differentiation IMP
IMP: 通过突变表型推断
16715081 MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation IGI
IGI: 通过遗传相互作用推断
18287202 MGI
acts upstream of or within spinal cord oligodendrocyte cell fate specification IMP
IMP: 通过突变表型推断
18287202 MGI
acts upstream of or within stomach neuroendocrine cell differentiation IMP
IMP: 通过突变表型推断
18173746 MGI
acts upstream of or within subpallium neuron fate commitment IMP
IMP: 通过突变表型推断
9876181 MGI
involved in sympathetic ganglion development IMP
IMP: 通过突变表型推断
18094025 MGI
involved in ventral spinal cord interneuron fate commitment IMP
IMP: 通过突变表型推断
16020526 MGI
acts upstream of or within vestibular nucleus development IMP
IMP: 通过突变表型推断
12885554 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuronal cell body IDA
IDA: 通过直接分析推断
11133151 MGI
located in nucleus IDA
IDA: 通过直接分析推断
1576967 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

achaete-scute homolog 1

achaete-scute complex homolog-like 1

achaete-scute complex-like protein 1

mammalian achaete scute homolog 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01078 ASCL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21486 Ascl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28004 Ascl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ascl1 NCBI NCBI:429
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