2. Gene
  3. Mbd4 - methyl-CpG binding domain protein 4 Gene

Mbd4 - methyl-CpG binding domain protein 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Med1

基因 ID: 17193 | 基因类型: protein coding

关于 Mbd4

功能概要

Enables DNA binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2 DNA damage checkpoint signaling; and response to radiation. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including central nervous system; lower urogenital tract; reproductive system; retina; and urethra epithelium. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus squamous cell carcinoma; lung cancer; and rheumatoid arthritis. Orthologous to human MBD4 (methyl-CpG binding domain 4, DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]

Mbd4 基因产物(6)

mRNA Protein Name
NM_001410106.1 NP_001397035.1 methyl-CpG-binding domain protein 4 isoform 2
NM_001410107.1 NP_001397036.1 methyl-CpG-binding domain protein 4 isoform 3
NM_001410108.1 NP_001397037.1 methyl-CpG-binding domain protein 4 isoform 4
NM_001410109.1 NP_001397038.1 methyl-CpG-binding domain protein 4 isoform 5
NM_001410110.1 NP_001397039.1 methyl-CpG-binding domain protein 4 isoform 6
NM_010774.3 NP_034904.2 methyl-CpG-binding domain protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9774669 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
14562041 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
14562041 MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
14614141 MGI
acts upstream of or within response to radiation IMP
IMP: 通过突变表型推断
14562041 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
9774669 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17546630 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9774669 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

methyl-CpG-binding domain protein 4

methyl-CpG-binding protein MBD4

mismatch-specific DNA N-glycosylase

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08184 MBD4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19616 Mbd4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26111 Mbd4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mbd4 NCBI NCBI:8930
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