2. Gene
  3. Mlh1 - mutL homolog 1 Gene

Mlh1 - mutL homolog 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 1110035C23Rik

基因 ID: 17350 | 基因类型: protein coding

关于 Mlh1

功能概要

Enables chromatin binding activity and guanine/thymine mispair binding activity. Involved in positive regulation of isotype switching to IgA isotypes and positive regulation of isotype switching to IgG isotypes. Acts upstream of or within several processes, including gamete generation; meiotic nuclear division; and nucleic acid metabolic process. Located in condensed nuclear chromosome and male germ cell nucleus. Part of MutLalpha complex. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; oral epithelium; and respiratory system. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system Cancer (multiple); lung cancer; mismatch repair Cancer syndrome; and sporadic breast Cancer. Orthologous to human MLH1 (mutL homolog 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlh1 基因产物(2)

mRNA Protein Name
NM_001324522.1 NP_001311451.1 DNA mismatch repair protein Mlh1 isoform 2
NM_026810.2 NP_081086.2 DNA mismatch repair protein Mlh1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
14716311 MGI
enables guanine/thymine mispair binding IGI
IGI: 通过遗传相互作用推断
16713580 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IGI
IGI: 通过遗传相互作用推断
9560238 MGI
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
14562041 MGI
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
13679151 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
15084308 MGI
acts upstream of or within female meiosis chromosome segregation IMP
IMP: 通过突变表型推断
25533956 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: 通过突变表型推断
8674118 MGI
acts upstream of or within homologous chromosome segregation IMP
IMP: 通过突变表型推断
25533956 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
14562041 MGI
acts upstream of or within isotype switching IMP
IMP: 通过突变表型推断
12743174 MGI
acts upstream of or within leptotene IMP
IMP: 通过突变表型推断
17010969 MGI
acts upstream of or within male meiosis chromosome segregation IMP
IMP: 通过突变表型推断
25533956 MGI
acts upstream of or within male meiotic nuclear division IMP
IMP: 通过突变表型推断
15467367 MGI
acts upstream of or within meiotic cell cycle IDA
IDA: 通过直接分析推断
12091911 MGI
acts upstream of or within meiotic chromosome segregation IMP
IMP: 通过突变表型推断
12217320 MGI
acts upstream of or within meiotic metaphase I homologous chromosome alignment IMP
IMP: 通过突变表型推断
10385520 MGI
acts upstream of or within meiotic spindle midzone assembly IMP
IMP: 通过突变表型推断
10385520 MGI
acts upstream of or within meiotic telomere clustering IMP
IMP: 通过突变表型推断
17010969 MGI
acts upstream of or within mismatch repair IDA
IDA: 通过直接分析推断
10747038 MGI
acts upstream of or within mismatch repair IMP
IMP: 通过突变表型推断
8674118 MGI
acts upstream of or within negative regulation of mitotic recombination IMP
IMP: 通过突变表型推断
15480418 MGI
acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening IMP
IMP: 通过突变表型推断
11337385 MGI
acts upstream of or within oogenesis IMP
IMP: 通过突变表型推断
8674118 MGI
involved in positive regulation of isotype switching to IgA isotypes IMP
IMP: 通过突变表型推断
10430621 MGI
involved in positive regulation of isotype switching to IgG isotypes IMP
IMP: 通过突变表型推断
10430621 MGI
acts upstream of or within reciprocal meiotic recombination IMP
IMP: 通过突变表型推断
8673133 MGI
acts upstream of or within resolution of meiotic recombination intermediates IMP
IMP: 通过突变表型推断
10385520 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: 通过突变表型推断
10092760 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IMP
IMP: 通过突变表型推断
11828012 MGI
acts upstream of or within somatic recombination of immunoglobulin genes involved in immune response IGI
IGI: 通过遗传相互作用推断
12743174 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
8674118 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MutLalpha complex IDA
IDA: 通过直接分析推断
16713580 MGI
located in chiasma IDA
IDA: 通过直接分析推断
17291760 MGI
located in chromosome IDA
IDA: 通过直接分析推断
11934988 MGI
located in condensed chromosome IDA
IDA: 通过直接分析推断
12091911 MGI
located in condensed chromosome IMP
IMP: 通过突变表型推断
8673133 MGI
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
18316482 MGI
located in late recombination nodule IDA
IDA: 通过直接分析推断
27760146 MGI
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
17696610 MGI
located in synaptonemal complex IDA
IDA: 通过直接分析推断
15467367 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA mismatch repair protein Mlh1

colon cancer, nonpolyposis type 2

mutL protein homolog 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08489 MLH1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19146 Mlh1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25637 Mlh1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mlh1 NCBI NCBI:4292
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