2. Gene
  3. Fam89b - family with sequence similarity 89, member B Gene

Fam89b - family with sequence similarity 89, member B Gene

  • 基因
  • 蛋白

种属: Mus musculus

同用名: MMTV; Mtvr2; 1110021A21Rik

基因 ID: 17826 | 基因类型: protein coding

关于 Fam89b

功能概要

Enables transcription corepressor binding activity. Involved in establishment of cell polarity; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of cell migration. Located in cytoplasm and lamellipodium. Is expressed in several structures, including branchial arch; cranial ganglion; heart valve; medulla oblongata basal plate mantle layer; and sensory organ. Orthologous to human FAM89B (family with sequence similarity 89 member B). [provided by Alliance of Genome Resources, Apr 2022]

Fam89b 基因产物(2)

mRNA Protein Name
NM_023166.2 NP_075655.2 leucine repeat adapter protein 25 isoform 2
NM_181452.2 NP_852117.2 leucine repeat adapter protein 25 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12646588 MGI
enables transcription corepressor binding IDA
IDA: 通过直接分析推断
12646588 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in establishment of cell polarity IMP
IMP: 通过突变表型推断
25107909 MGI
involved in negative regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
12646588 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
12646588 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
25107909 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12646588 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
25107909 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

leucine repeat adapter protein 25

C184L ORF2 protein

C184M protein

MMTV receptor

mammary tumor virus receptor 2

protein FAM89B

Fam89b 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Fam89b Q9QUI1 SKI Homo sapiens P12755
Confocal
12646588
种属间
Fam89b Q9QUI1 SKI Homo sapiens P12755
Pull Down
12646588
种属间: 跨种属相互作用 种属内: 同种属相互作用
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