Nog - noggin Gene

种属: Mus musculus

基因 ID: 18121 | 基因类型: protein coding

关于 Nog

功能概要

Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including branchial arch; embryo ectoderm; heart; limb; and sensory organ. Used to study esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism (multiple). Orthologous to human NOG (noggin). [provided by Alliance of Genome Resources, Apr 2022]

Nog 基因产物(1)

mRNA	Protein	Name
NM_008711.2	NP_032737.1	noggin precursor

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of BMP signaling pathway	IDA IDA: 通过直接分析推断	18462699	MGI
involved in BMP signaling pathway	IDA IDA: 通过直接分析推断	17634368	MGI
involved in BMP signaling pathway	IGI IGI: 通过遗传相互作用推断	12397106	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: 通过遗传相互作用推断	16916379	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: 通过突变表型推断	16916379	MGI
involved in atrial cardiac muscle tissue morphogenesis	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within axial mesoderm development	IMP IMP: 通过突变表型推断	16712836	MGI
acts upstream of or within axon guidance	IMP IMP: 通过突变表型推断	12435358	MGI
acts upstream of or within brain development	IMP IMP: 通过突变表型推断	12397106	MGI
acts upstream of cartilage development	IDA IDA: 通过直接分析推断	10684250	MGI
involved in cell population proliferation	IGI IGI: 通过遗传相互作用推断	12397106	MGI
acts upstream of or within cellular response to BMP stimulus	IDA IDA: 通过直接分析推断	20501701	MGI
acts upstream of or within central nervous system development	IMP IMP: 通过突变表型推断	10688202	MGI
involved in cranial skeletal system development	IGI IGI: 通过遗传相互作用推断	12397106	MGI
involved in endocardial cushion formation	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within endoderm development	IDA IDA: 通过直接分析推断	24835669	MGI
acts upstream of or within endoderm formation	IDA IDA: 通过直接分析推断	18462699	MGI
acts upstream of epithelial cell proliferation	IGI IGI: 通过遗传相互作用推断	18028901	MGI
acts upstream of epithelial cell proliferation	IMP IMP: 通过突变表型推断	18028901	MGI
involved in epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	17218603	MGI
involved in exploration behavior	IMP IMP: 通过突变表型推断	17634368	MGI
acts upstream of or within face morphogenesis	IMP IMP: 通过突变表型推断	16712836	MGI
involved in fibroblast growth factor receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	12397106	MGI
involved in forebrain development	IGI IGI: 通过遗传相互作用推断	10688202	MGI
involved in heart trabecula morphogenesis	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within in utero embryonic development	IMP IMP: 通过突变表型推断	17359964	MGI
involved in long-term synaptic potentiation	IMP IMP: 通过突变表型推断	17634368	MGI
acts upstream of or within lung morphogenesis	IMP IMP: 通过突变表型推断	16712836	MGI
involved in membranous septum morphogenesis	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within mesenchymal cell differentiation	IMP IMP: 通过突变表型推断	18028901	MGI
acts upstream of or within mesoderm formation	IDA IDA: 通过直接分析推断	18462699	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: 通过突变表型推断	12435358	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: 通过直接分析推断	15110716	MGI
involved in negative regulation of BMP signaling pathway	IDA IDA: 通过直接分析推断	17360443	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IGI IGI: 通过遗传相互作用推断	19852960	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IMP IMP: 通过突变表型推断	16712836	MGI
involved in negative regulation of BMP signaling pathway	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IMP IMP: 通过突变表型推断	16712836	MGI
involved in negative regulation of astrocyte differentiation	IMP IMP: 通过突变表型推断	18028109	MGI
involved in negative regulation of cardiac epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	17218603	MGI
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within negative regulation of cartilage development	IDA IDA: 通过直接分析推断	10684250	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: 通过直接分析推断	21624478	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within neural plate morphogenesis	IMP IMP: 通过突变表型推断	16712836	MGI
acts upstream of or within neural tube closure	IMP IMP: 通过突变表型推断	16712836	MGI
acts upstream of or within neural tube development	IMP IMP: 通过突变表型推断	9585504	MGI
acts upstream of or within notochord morphogenesis	IMP IMP: 通过突变表型推断	16916379	MGI
involved in osteoblast differentiation	IMP IMP: 通过突变表型推断	10780858	MGI
involved in outflow tract morphogenesis	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within pattern specification process	IMP IMP: 通过突变表型推断	12397106	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: 通过突变表型推断	17218603	MGI
acts upstream of or within pituitary gland development	IMP IMP: 通过突变表型推断	17359964	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IDA IDA: 通过直接分析推断	12141440	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: 通过遗传相互作用推断	18028901	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: 通过突变表型推断	18028901	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	17218603	MGI
involved in positive regulation of glomerulus development	IDA IDA: 通过直接分析推断	12141440	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9585504	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	9585504	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	17634368	MGI
acts upstream of or within prostatic bud formation	IMP IMP: 通过突变表型推断	18028901	MGI
acts upstream of or within regulation of BMP signaling pathway	IMP IMP: 通过突变表型推断	17359964	MGI
involved in regulation of neuronal synaptic plasticity	IMP IMP: 通过突变表型推断	17634368	MGI
involved in short-term synaptic potentiation	IMP IMP: 通过突变表型推断	17634368	MGI
acts upstream of or within skeletal system development	IMP IMP: 通过突变表型推断	11784076	MGI
involved in smoothened signaling pathway	IGI IGI: 通过遗传相互作用推断	12397106	MGI
acts upstream of or within somite development	IMP IMP: 通过突变表型推断	16712836	MGI
involved in specification of segmental identity, mandibular segment	IGI IGI: 通过遗传相互作用推断	11784076	MGI
acts upstream of or within spinal cord development	IMP IMP: 通过突变表型推断	16712836	MGI
acts upstream of or within stem cell differentiation	IMP IMP: 通过突变表型推断	18028901	MGI
acts upstream of or within ureteric bud development	IDA IDA: 通过直接分析推断	12141440	MGI
involved in ureteric bud formation	IDA IDA: 通过直接分析推断	17522159	MGI
acts upstream of or within urogenital system development	IMP IMP: 通过突变表型推断	18028901	MGI
involved in ventricular compact myocardium morphogenesis	IMP IMP: 通过突变表型推断	17218603	MGI
involved in ventricular septum morphogenesis	IMP IMP: 通过突变表型推断	17218603	MGI
involved in visual learning	IMP IMP: 通过突变表型推断	17634368	MGI
involved in wound healing	IMP IMP: 通过突变表型推断	18028109	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	15110716	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

noggin

重组 Nog 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7086	Noggin Protein, Mouse (CHO)	P97466 (L20-C232)	≥95%
HY-P70785	Noggin Protein, Mouse (HEK293, His)	P97466 (Q28-C232)	≥95%
HY-P73323	Noggin Protein, Mouse (HEK293, Fc)	P97466 (Q28-C232)	≥95%
HY-P700286	Noggin Protein, Mouse (HEK293)	P97466 (Q28-C232)	≥95%

目录号	产品名	作用方式	纯度	Phase
HY-P99836	Cudarolimab	Inhibitor	95.00%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-170451	KT-253		98.53%	否
HY-163532	FLS-359	Modulator	/	否
HY-170452	MDM2 ligand 4	Ligand	/	否
HY-175236	SF-9-2		/	否
HY-RS09410	NOG Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17067	Nog Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23511	Nog Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P991587	SAR-446523	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Nog	NCBI	NCBI:9241
Canis familiaris	Nog	NCBI	NCBI:100683515
Macaca fascicularis	Nog	NCBI	NCBI:102145726
Leporidae	Nog	NCBI
Rattus norvegicus	Nog	NCBI	NCBI:25495
Macaca mulatta	Nog	NCBI	NCBI:707338

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Nog - noggin Gene

关于 Nog

功能概要

Nog 基因产物(1)

重组 Nog 蛋白

直系同源

热门区域

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Nog - noggin Gene

关于 Nog

功能概要

Nog 基因产物(1)

重组 Nog 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z