ECH1 - enoyl-CoA hydratase 1 Gene

中文名称：烯酰辅酶 A 水合酶 1

种属: Homo sapiens

同用名: HPXEL

关于 ECH1

功能概要

该基因编码水合酶/异构酶超家族的一个成员。该基因产物显示出与几种物种的烯酰辅酶 A (CoA) 水合酶的高度序列相似性，特别是在这些蛋白质的保守结构域内。编码的蛋白质含有 C 端过氧化物酶体靶向序列，定位于过氧化物酶体。定位于过氧化物酶体和线粒体基质的大鼠直系同源物可将 3-反式、5-顺式二烯酰辅酶 A 异构化为 2-反式、4-反式二烯酰辅酶 A，表明它是 delta3,5 -delta2,4-二烯酰辅酶 A 异构酶。这种酶在脂肪酸 β-氧化途径的辅助步骤中发挥作用。大鼠基因的表达是由过氧化物酶体增殖物诱导的。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]