2. Gene
  3. Pxn - paxillin Gene

Pxn - paxillin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pax

基因 ID: 19303 | 基因类型: protein coding

关于 Pxn

功能概要

Enables BH4 domain binding activity; MAP-kinase scaffold activity; and neuropilin binding activity. Involved in positive regulation of angiogenesis and transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including focal adhesion assembly; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Located in focal adhesion and lamellipodium. Is expressed in several structures, including early conceptus; genitourinary system; immune system; inner ear; and telencephalon. Orthologous to human PXN (paxillin). [provided by Alliance of Genome Resources, Apr 2022]

Pxn 基因产物(7)

mRNA Protein Name
NM_001403066.1 NP_001389995.1 paxillin isoform 3
NM_001403067.1 NP_001389996.1 paxillin isoform 4
NM_001403068.1 NP_001389997.1 paxillin isoform 5
NM_001403069.1 NP_001389998.1 paxillin isoform 5
NM_001403070.1 NP_001389999.1 paxillin isoform 5
NM_011223.4 NP_035353.1 paxillin isoform alpha
NM_133915.4 NP_598676.2 paxillin isoform beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BH4 domain binding IPI
IPI: 通过物理相互作用推断
14699151 MGI
enables MAP-kinase scaffold activity IDA
IDA: 通过直接分析推断
14636584 MGI
enables neuropilin binding IPI
IPI: 通过物理相互作用推断
24863063 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9418872 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within branching morphogenesis of an epithelial tube IDA
IDA: 通过直接分析推断
14636584 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
11784865 MGI
acts upstream of or within cytoskeleton organization IMP
IMP: 通过突变表型推断
11784865 MGI
acts upstream of or within focal adhesion assembly IDA
IDA: 通过直接分析推断
14636584 MGI
acts upstream of or within integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
11784865 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: 通过直接分析推断
14636584 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
15467718 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
24863063 MGI
acts upstream of or within positive regulation of protein kinase activity IMP
IMP: 通过突变表型推断
23658024 MGI
acts upstream of or within regulation of cell shape IMP
IMP: 通过突变表型推断
23658024 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
23658024 MGI
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
24036928 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell leading edge IDA
IDA: 通过直接分析推断
18794329 MGI
located in focal adhesion IDA
IDA: 通过直接分析推断
10809671 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
14636584 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

paxillin

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11479 PXDN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11484 PXN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17322 Pxn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23777 Pxn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pxn NCBI NCBI:5829
Macaca fascicularis Pxn NCBI NCBI:102138249
Rattus norvegicus Pxn NCBI NCBI:360820
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