2. Gene
  3. Rac2 - Rac family small GTPase 2 Gene

Rac2 - Rac family small GTPase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 19354 | 基因类型: protein coding

关于 Rac2

功能概要

Enables GTPase activity and protein kinase regulator activity. Involved in positive regulation of lamellipodium assembly; regulation of leukocyte activation; and regulation of leukocyte chemotaxis. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; actin Cytoskeleton organization; and cell projection assembly. Located in cytoplasm; membrane; and nuclear envelope. Is expressed in heart. Used to study immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]

Rac2 基因产物(1)

mRNA Protein Name
NM_009008.3 NP_033034.1 ras-related C3 botulinum toxin substrate 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
15249579 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18264091 MGI
enables protein kinase regulator activity IMP
IMP: 通过突变表型推断
10843388 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
21178006 MGI
acts upstream of or within actin cytoskeleton organization IDA
IDA: 通过直接分析推断
12176888 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
11435472 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
11435472 MGI
acts upstream of or within cell projection assembly IDA
IDA: 通过直接分析推断
12176888 MGI
acts upstream of or within chemotaxis IDA
IDA: 通过直接分析推断
12176888 MGI
acts upstream of or within erythrocyte enucleation IMP
IMP: 通过突变表型推断
18264091 MGI
acts upstream of mast cell proliferation IGI
IGI: 通过遗传相互作用推断
11435472 MGI
acts upstream of mast cell proliferation IMP
IMP: 通过突变表型推断
11435472 MGI
involved in positive regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
19625648 MGI
acts upstream of or within positive regulation of mast cell proliferation IGI
IGI: 通过遗传相互作用推断
11435472 MGI
acts upstream of or within positive regulation of mast cell proliferation IMP
IMP: 通过突变表型推断
11435472 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: 通过突变表型推断
19625648 MGI
involved in regulation of T cell proliferation IMP
IMP: 通过突变表型推断
11581314 MGI
involved in regulation of mast cell chemotaxis IMP
IMP: 通过突变表型推断
10843388 MGI
involved in regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
10843388 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12176888 MGI
located in membrane IDA
IDA: 通过直接分析推断
12176888 MGI
located in nuclear envelope IDA
IDA: 通过直接分析推断
12176888 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ras-related C3 botulinum toxin substrate 2

EN-7 protein

RAS-related C3 botulinum substrate 2

p21-Rac2

protein EN-7

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16659 EHT 1864 Inhibitor 99.85% 否
HY-113849 MLS-573151 Inhibitor 99.70% 否
HY-132316S (rac)-2,4-O-Dimethylzearalenone-d6 / 否
HY-RS11592 RAC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W051624S (Rac)-2-Aminothiazoline-4-carboxylic acid-13C,15N2 / 否
HY-W704952 rac 2-(tert-Butyldimethylsilyloxy) Ibuprofen-d6 / 否
HY-143681S (Rac)-2-Palmitoyl-3-chloropropanediol-d5 / 否
HY-RS17270 Rac2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23724 Rac2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W010590S (Rac)-2-Aminobutyric acid-d3 / 否
HY-W778187 rac 2-Oleoyl-3-chloropropanediol-d5,95% / 否
HY-W778189 rac-2-Linoleoyl-3-chloropropanediol-d5,95% / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rac2 NCBI NCBI:5880
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