2. Gene
  3. KLHDC8B - kelch domain containing 8B Gene

KLHDC8B - kelch domain containing 8B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 kelch 结构域 8B

种属: Homo sapiens

同用名: CHL

基因 ID: 200942 | 基因类型: protein coding

关于 KLHDC8B

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,171,598-49,176,486 (from NCBI)

This gene has 5 transcripts (splice variants), 125 orthologues, 54 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 31.3), ovary (RPKM 23.4) and 23 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质形成 kelch 结构域的独特 β-螺旋桨蛋白质结构，允许蛋白质-蛋白质相互作用。该基因的突变与霍奇金淋巴瘤有关。[RefSeq 提供，2010 年 9 月]

This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]

KLHDC8B 基因产物(1)

mRNA Protein Name
NM_173546.3 NP_775817.1 kelch domain-containing protein 8B
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic cytokinetic process IMP
IMP: 通过突变表型推断
20107318 GOA
involved in mitotic nuclear division IMP
IMP: 通过突变表型推断
20107318 GOA
involved in nuclear chromosome segregation IMP
IMP: 通过突变表型推断
22988245 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cellularization cleavage furrow IDA
IDA: 通过直接分析推断
20107318 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
20107318 GOA
located in intercellular bridge IDA
IDA: 通过直接分析推断
20107318 GOA
located in midbody IDA
IDA: 通过直接分析推断
20107318 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLHDC8B 蛋白结构

Kelch_3

Kelch_3: Galactose oxidase, central domain (31 - 76)

Kelch_1

Kelch_1: Kelch motif (118 - 162)

Kelch_4

Kelch_4: Galactose oxidase, central domain (165 - 210)

Kelch_1

Kelch_1: Kelch motif (211 - 262)

Kelch_6

Kelch_6: Kelch motif (273 - 319)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

kelch domain-containing protein 8B

关联疾病

疾病名称 别名
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Hodgkin'S Lymphoma, Nodular Sclerosis

Classical Hodgkin Lymphoma, Nodular Sclerosis

Classic Hodgkin Lymphoma, Nodular Sclerosis Type

Nodular Sclerosis Hodgkin Lymphoma

Hodgkin'S Disease, Nodular Sclerosis

Hodgkin Disease, Nodular Sclerosis

Hodgkin Lymphoma, Nodular Sclerosis

Hodgkin Nodular Sclerosis
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07353 KLHDC8B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KLHDC8B VGNC VGNC:42444
Macaca mulatta KLHDC8B VGNC VGNC:74142
Rattus norvegicus KLHDC8B RGD RGD:1359445
Bos taurus KLHDC8B VGNC VGNC:30640
Felis catus KLHDC8B VGNC VGNC:63140
Mus musculus KLHDC8B MGD MGI:1925517
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