2. Gene
  3. ENDOG - endonuclease G Gene

ENDOG - endonuclease G Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核酸内切酶 G

种属: Homo sapiens

基因 ID: 2021 | 基因类型: protein coding

关于 ENDOG

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,818,500-128,822,676 (from NCBI)

This gene has 1 transcript (splice variant), 180 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 10.6), prostate (RPKM 9.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种核编码的核酸内切酶，位于线粒体中。编码的蛋白质广泛分布于动物中，并在 GC 道切割 DNA。这种蛋白质能够产生 DNA 聚合酶 γ 启动线粒体 DNA 复制所需的 RNA 引物。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a nuclear encoded Endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among Animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA Polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

ENDOG 基因产物(1)

mRNA Protein Name
NM_004435.2 NP_004426.2 endonuclease G, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA endonuclease activity IMP
IMP: 通过突变表型推断
25355512 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25036637 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
33473107 GOA
involved in mitochondrial DNA catabolic process IMP
IMP: 通过突变表型推断
29719607 GOA
involved in negative regulation of TOR signaling IMP
IMP: 通过突变表型推断
33473107 GOA
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
33473107 GOA
involved in positive regulation of mitochondrial DNA replication IMP
IMP: 通过突变表型推断
29719607 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
33473107 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ENDOG 蛋白结构

Endonuclease_NS

Endonuclease_NS: DNA/RNA non-specific endonuclease (78 - 282)

  • 0
  • 100
  • 200
  • 297 a.a.
蛋白主名 其他名称

endonuclease G, mitochondrial

endo G

ENDOG 抗体

目录号 产品名 应用 反应物种
HY-P81784 Endo G Antibody (YA1529) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04371 ENDOG Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS19189 Endog Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS25677 Endog Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ENDOG VGNC VGNC:61859
Bos taurus ENDOG VGNC VGNC:28491
Mus musculus ENDOG MGD MGI:1261433
Macaca mulatta ENDOG VGNC VGNC:72218
Rattus norvegicus ENDOG RGD RGD:1310763
Canis familiaris ENDOG VGNC VGNC:40360
Others ENDOG NCBI
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