2. Gene
  3. Scn10a - sodium channel, voltage-gated, type X, alpha Gene

Scn10a - sodium channel, voltage-gated, type X, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：钠通道，电压门控，X 型， α

种属: Mus musculus

同用名: PN3; SNS; Nav1.8

基因 ID: 20264 | 基因类型: protein coding

关于 Scn10a

Chromosome 9: 119,437,522-119,548,388 reverse strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 331 orthologues, 26 paralogues and is associated with 18 phenotypes. Biased expression in heart adult (RPKM 1.), CNS E18 (RPKM .5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动电压门控钠通道活动。作用于心脏传导的上游或内部；调节心房心肌细胞膜去极化；和钠离子运输。位于C-纤维和质膜。在大脑中表达；神经节;和心。该基因的人类直向同源物与家族性发作性疼痛综合征 2 相关。与人类 SCN10A（钠电压门控通道 α 亚基 10）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables voltage-gated Sodium Channel activity. Acts upstream of or within cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; and sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in brain; ganglia; and heart. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Apr 2022]

Scn10a 基因产物(2)

mRNA Protein Name
NM_009134.3 NP_033160.2 sodium channel protein type 10 subunit alpha isoform 2
NM_001205321.1 NP_001192250.1 sodium channel protein type 10 subunit alpha isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables voltage-gated sodium channel activity IDA
IDA: 通过直接分析推断
16029194 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to pain IMP
IMP: 通过突变表型推断
24440715 MGI
acts upstream of or within cardiac conduction IMP
IMP: 通过突变表型推断
20062061 MGI
involved in circadian rhythm IMP
IMP: 通过突变表型推断
25101983 MGI
involved in detection of mechanical stimulus involved in sensory perception IMP
IMP: 通过突变表型推断
25101983 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
19931571 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: 通过直接分析推断
16029194 MGI
acts upstream of or within regulation of atrial cardiac muscle cell membrane depolarization IMP
IMP: 通过突变表型推断
20062061 MGI
acts upstream of or within sodium ion transport IDA
IDA: 通过直接分析推断
16029194 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in C-fiber IDA
IDA: 通过直接分析推断
16029194 MGI
located in axon IDA
IDA: 通过直接分析推断
16029194 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16029194 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Scn10a 蛋白结构

Ion_trans

Ion_trans: pfam00520 (128 - 405)

Ion_trans

Ion_trans: pfam00520 (662 - 892)

Na_trans_assoc

Na_trans_assoc: pfam06512 (902 - 1146)

Ion_trans

Ion_trans: pfam00520 (1150 - 1426)

Na_channel_gate

Na_channel_gate: cd13433 (1418 - 1470)

Ion_trans

Ion_trans: pfam00520 (1474 - 1731)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1957 a.a.
蛋白主名 其他名称

sodium channel protein type 10 subunit alpha

peripheral nerve sodium channel 3

sensory neuron sodium channel

sodium channel protein type X subunit alpha

voltage gated sodium channel

voltage-gated sodium channel subunit alpha Nav1.8

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12519 SCN10A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS12520 Scn10a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS12521 Scn10a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scn10a NCBI NCBI:6336
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