Slc1a2 - solute carrier family 1 (glial high affinity glutamate transporter), member 2 Gene

中文名称：溶质载体家族 1 (胶质高亲和力谷氨酸转运蛋白) ，成员 2

种属: Mus musculus

同用名: GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik

关于 Slc1a2

功能概要

该基因编码的蛋白可启动半胱氨酸跨膜转运蛋白活性和高亲和力谷氨酸跨膜转运蛋白活性。参与多个过程，包括跨质膜输入 L-谷氨酸；细胞对可卡因的反应；和谷胱甘肽的生物合成过程。作用于多个过程的上游或内部，包括 L-谷氨酸跨膜转运；积极调节葡萄糖输入；和视觉行为。位于几种细胞成分中，包括星形胶质细胞投射；轴突；和膜筏。是质膜的组成部分。在谷氨酸能突触中活跃。以多种结构表达，包括消化系统；脑;泌尿生殖系统；淋巴系统腺体；和脊髓。该基因的人类直向同源基因与发育和癫痫性脑病 41 相关。与人类 SLC1A2（溶质载体家族 1 成员 2）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine transmembrane transporter activity and high-affinity glutamate transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; positive regulation of glucose import; and visual behavior. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]