2. Gene
  3. Stxbp1 - syntaxin binding protein 1 Gene

Stxbp1 - syntaxin binding protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ms10g; nsec1; N-sec1; Sxtbp1; Unc18h; MMS10-G; Rb-sec1; Unc18-1; Munc-18a; Munc18-1

基因 ID: 20910 | 基因类型: protein coding

关于 Stxbp1

功能概要

Enables syntaxin-1 binding activity. Involved in presynaptic dense core vesicle exocytosis and synaptic vesicle priming. Acts upstream of or within several processes, including axon target recognition; chemical synaptic transmission; and negative regulation of synaptic transmission. Located in several cellular components, including glutamatergic synapse; phagocytic vesicle; and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4. Orthologous to human STXBP1 (syntaxin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp1 基因产物(2)

mRNA Protein Name
NM_001113569.1 NP_001107041.1 syntaxin-binding protein 1 isoform a
NM_009295.2 NP_033321.2 syntaxin-binding protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7598732 MGI
enables syntaxin-1 binding IDA
IDA: 通过直接分析推断
18703708 MGI
enables syntaxin-1 binding IPI
IPI: 通过物理相互作用推断
7890599 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within axon target recognition IMP
IMP: 通过突变表型推断
15182301 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: 通过直接分析推断
19144319 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
11545717 MGI
acts upstream of or within exocytosis IMP
IMP: 通过突变表型推断
11545717 MGI
acts upstream of or within long-term synaptic depression IMP
IMP: 通过突变表型推断
17110441 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
15255974 MGI
acts upstream of or within negative regulation of synaptic transmission, GABAergic IDA
IDA: 通过直接分析推断
17167098 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: 通过突变表型推断
17110441 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
15255974 MGI
acts upstream of or within neurotransmitter secretion IMP
IMP: 通过突变表型推断
15255974 MGI
acts upstream of or within positive regulation of calcium ion-dependent exocytosis IDA
IDA: 通过直接分析推断
15123626 MGI
acts upstream of or within synaptic vesicle maturation IMP
IMP: 通过突变表型推断
15145078 MGI
involved in synaptic vesicle priming IDA
IDA: 通过直接分析推断
17110441 MGI
involved in synaptic vesicle priming IMP
IMP: 通过突变表型推断
17110441 MGI
acts upstream of or within vesicle docking involved in exocytosis IMP
IMP: 通过突变表型推断
11545717 MGI
involved in vesicle docking involved in exocytosis IMP
IMP: 通过突变表型推断
18703708 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
23821748 MGI
is active in extrinsic component of presynaptic membrane IDA
IDA: 通过直接分析推断
24590174 MGI
is active in extrinsic component of presynaptic membrane IMP
IMP: 通过突变表型推断
24590174 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17110441 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17110441 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
32494600 MGI
located in phagocytic vesicle IDA
IDA: 通过直接分析推断
19144319 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
23821748 MGI
is active in presynaptic active zone cytoplasmic component IDA
IDA: 通过直接分析推断
32494600 MGI
is active in presynaptic cytosol IDA
IDA: 通过直接分析推断
24590174 MGI
is active in presynaptic cytosol IMP
IMP: 通过突变表型推断
24590174 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

syntaxin-binding protein 1

UNC-18 homolog

minisatellite 10g detected by probe MMS10

protein unc-18 homolog 1

protein unc-18 homolog A

unc-18-1

unc-18A

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13989 STXBP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21950 Stxbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stxbp1 NCBI NCBI:6812
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