2. Gene
  3. ETV3 - ETS variant transcription factor 3 Gene

ETV3 - ETS variant transcription factor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ETS 变体转录因子 3

种属: Homo sapiens

同用名: PE1; METS; PE-1

基因 ID: 2117 | 基因类型: protein coding

关于 ETV3

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,121,191-157,138,395 (from NCBI)

This gene has 3 transcripts (splice variants), 125 orthologues and 28 paralogues. Ubiquitous expression in skin (RPKM 12.1), gall bladder (RPKM 6.8) and 25 other tissues.

功能概要

启用序列特异性双链 DNA 结合活性。预测通过 RNA 聚合酶 II 参与细胞分化和转录调控。预计在 RNA 聚合酶 II 的转录负调节上游或负调节内起作用。位于核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ETV3 基因产物(2)

mRNA Protein Name
NM_001145312.3 NP_001138784.1 ETS translocation variant 3 isoform 1
NM_005240.3 NP_005231.1 ETS translocation variant 3 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ETV3 蛋白结构

Ets

Ets: Ets-domain (34 - 117)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 512 a.a.
蛋白主名 其他名称

ETS translocation variant 3

ETS domain transcriptional repressor PE1

关联疾病

疾病名称 别名
Hypotrichosis 1

HYPT1

Hhs

Hts

Hypotrichosis Simplex

Hypotrichosis Simplex, Generalized, Hereditary

Hereditary Generalized Hypotrichosis Simplex

Generalized Hypothricosis Simplex

Hypotrichosis Simplex Hereditary

Hypotrichosis, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04566 ETV3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21337 Etv3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27856 Etv3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ETV3 VGNC VGNC:50176
Canis familiaris ETV3 VGNC VGNC:53343
Rattus norvegicus ETV3 RGD RGD:1311577
Macaca mulatta ETV3 VGNC VGNC:99918
Mus musculus ETV3 MGD MGI:1350926
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