Tbx6 - T-box 6 Gene

种属: Mus musculus

同用名: rv

关于 Tbx6

功能概要

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of neuron maturation; regulation of gene expression; and somite rostral/caudal axis specification. Located in chromatin and nucleus. Is expressed in several structures, including 4-cell stage embryo; embryo ectoderm; embryo mesenchyme; genitourinary system; and primitive streak. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]