1. Gene
  2. Tgfb3 - transforming growth factor, beta 3 Gene

Tgfb3 - transforming growth factor, beta 3 Gene

种属: Mus musculus

同用名: Tgfb-3; TGF-beta-3

基因 ID: 21809 | 基因类型: protein coding

关于 Tgfb3

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Homozygous knockout mice for this gene exhibit cleft palate, delayed pulmonary development and neonatal death. [provided by RefSeq, Aug 2016]

Tgfb3 基因产物(1)

mRNA Protein Name
NM_009368.3 NP_033394.2 transforming growth factor beta-3 proprotein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28912269 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
14697364 MGI
acts upstream of cell population proliferation IDA
IDA: 通过直接分析推断
12815624 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
7848824 MGI
acts upstream of or within embryo development IMP
IMP: 通过突变表型推断
14729481 MGI
acts upstream of epithelial cell proliferation IDA
IDA: 通过直接分析推断
12815624 MGI
involved in face morphogenesis IEP
IEP: 通过表达模式推断
18498113 MGI
acts upstream of filopodium assembly IMP
IMP: 通过突变表型推断
16806156 MGI
acts upstream of or within positive effect gene expression IMP
IMP: 通过突变表型推断
16245336 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
14729481 MGI
involved in lung alveolus development IMP
IMP: 通过突变表型推断
7493022 MGI
acts upstream of or within mammary gland development IDA
IDA: 通过直接分析推断
1821856 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IDA
IDA: 通过直接分析推断
12815624 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
17159989 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
17159989 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
14691138 MGI
involved in positive regulation of SMAD protein signal transduction IMP
IMP: 通过突变表型推断
14691138 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
16806156 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
14691138 MGI
acts upstream of or within positive regulation of filopodium assembly IMP
IMP: 通过突变表型推断
16806156 MGI
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
21984612 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17159989 MGI
NOT involved in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
19161227 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
16245336 MGI
involved in secondary palate development IMP
IMP: 通过突变表型推断
7493021 MGI
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
14691138 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular matrix IDA
IDA: 通过直接分析推断
10521784 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

transforming growth factor beta-3 proprotein

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tgfb3 NCBI NCBI:7043
Rattus norvegicus Tgfb3 NCBI NCBI:25717