2. Gene
  3. Tie1 - tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Gene

Tie1 - tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: TIE; tie-1; D430008P04Rik

基因 ID: 21846 | 基因类型: protein coding

关于 Tie1

功能概要

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Tie1 基因产物(1)

mRNA Protein Name
NM_011587.2 NP_035717.2 tyrosine-protein kinase receptor Tie-1 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aortic valve morphogenesis IMP
IMP: 通过突变表型推断
31319059 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
23918385 MGI
involved in branching involved in lymph vessel morphogenesis IMP
IMP: 通过突变表型推断
20223757 MGI
acts upstream of or within in utero embryonic development IGI
IGI: 通过遗传相互作用推断
11172728 MGI
acts upstream of or within lymphatic endothelial cell differentiation IMP
IMP: 通过突变表型推断
20223757 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
9683559 MGI
acts upstream of or within negative regulation of cell migration IMP
IMP: 通过突变表型推断
9683559 MGI
acts upstream of or within plasma membrane fusion IMP
IMP: 通过突变表型推断
9683559 MGI
acts upstream of or within regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
20223757 MGI
acts upstream of regulation of extracellular matrix assembly IMP
IMP: 通过突变表型推断
31319059 MGI
involved in response to retinoic acid IDA
IDA: 通过直接分析推断
18439490 MGI
involved in tissue remodeling IMP
IMP: 通过突变表型推断
20223757 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
17717145 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase receptor Tie-1

tyrosine kinase receptor 1

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14514 TIAL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14520 TIE1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-15973 BSF-466895 Inhibitor / 否
HY-RS19390 Tie1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22860 Tial1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25882 Tie1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29374 Tial1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991384 DX-2240 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tie1 NCBI NCBI:7075
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