Tnfsf11 - tumor necrosis factor (ligand) superfamily, member 11 Gene

中文名称：肿瘤坏死因子 (配体) 超家族，成员 11

种属: Mus musculus

同用名: ODF; OPGL; RANKL; Ly109l; Trance

关于 Tnfsf11

功能概要

实现相同的蛋白质结合活性和肿瘤坏死因子受体超家族结合活性。参与多个过程，包括细胞内信号转导；细胞分泌的正调节；和肿瘤坏死因子介导的信号通路。作用于多个过程的上游或内部，包括动物器官发育；对细胞因子刺激的细胞反应；和细胞内信号转导的正调控。预计位于细胞质中；细胞外空间；和质膜。预计是膜的组成部分。在泌尿生殖系统中表达；淋巴系统；后肢长骨；和淋巴系统。用于研究常染色体隐性骨硬化病 2 和骨质疏松症。该基因的人类直系同源物与常染色体隐性骨硬化病 2 和骨质疏松症有关。与人类 TNFSF11（TNF 超家族成员 11）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF Superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]