2. Gene
  3. Tsg101 - tumor susceptibility gene 101 Gene

Tsg101 - tumor susceptibility gene 101 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CC2

基因 ID: 22088 | 基因类型: protein coding

关于 Tsg101

功能概要

Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate Cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]

Tsg101 基因产物(3)

mRNA Protein Name
NM_001348088.1 NP_001335017.1 tumor susceptibility gene 101 protein isoform 2
NM_001348089.1 NP_001335018.1 tumor susceptibility gene 101 protein isoform 3
NM_021884.4 NP_068684.1 tumor susceptibility gene 101 protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10888872 MGI
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
10888872 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell differentiation IDA
IDA: 通过直接分析推断
11943869 MGI
involved in exosomal secretion IMP
IMP: 通过突变表型推断
25392495 MGI
acts upstream of or within keratinocyte differentiation IDA
IDA: 通过直接分析推断
11943869 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11943869 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10888872 MGI
involved in positive regulation of ubiquitin-dependent endocytosis IMP
IMP: 通过突变表型推断
11916981 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: 通过直接分析推断
11943869 MGI
acts upstream of or within regulation of cell growth IDA
IDA: 通过直接分析推断
11943869 MGI
involved in viral budding IMP
IMP: 通过突变表型推断
15256501 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15256501 MGI
located in extracellular exosome IDA
IDA: 通过直接分析推断
24205035 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor susceptibility gene 101 protein

ESCRT-I complex subunit TSG101

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-17421 Tenatoprazole Inhibitor 99.75% 否
HY-P10845 KRL74 Inhibitor / 否
HY-RS15142 TSG101 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19082 Tsg101 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25573 Tsg101 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991414 FGI-1011A6 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tsg101 NCBI NCBI:7251
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