NSUN6 - NOP2/Sun RNA methyltransferase 6 Gene

中文名称：NOP2/Sun RNA 甲基转移酶 6

种属: Homo sapiens

同用名: NOPD1; ARL5B-AS1; 4933414E04Rik

基因 ID: 221078 | 基因类型: protein coding

关于 NSUN6

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:18,545,561-18,659,327 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues.

功能概要

启用 tRNA (cytosine-5-) -methyltransferase 活性和 tRNA 结合活性。参与 tRNA C5-胞嘧啶甲基化。位于细胞质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables tRNA (cytosine-5-)-methyltransferase activity and tRNA binding activity. Involved in tRNA C5-cytosine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NSUN6 基因产物(5)

mRNA	Protein	Name
NM_001351115.2	NP_001338044.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 2
NM_001351116.2	NP_001338045.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 3
NM_001351117.2	NP_001338046.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 4
NM_001351118.2	NP_001338047.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 5
NM_182543.5	NP_872349.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables tRNA (cytidine-5-)-methyltransferase activity	EXP EXP: 通过实验结果推断	26160102	GOA
enables tRNA (cytidine-5-)-methyltransferase activity	IDA IDA: 通过直接分析推断	26160102	GOA
enables tRNA binding	IDA IDA: 通过直接分析推断	26160102	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in tRNA C5-cytosine methylation	IDA IDA: 通过直接分析推断	26160102	GOA
involved in tRNA methylation	IDA IDA: 通过直接分析推断	28531330	GOA
involved in tRNA modification	IDA IDA: 通过直接分析推断	37226891	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	26160102	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NSUN6 蛋白结构

Methyltr_RsmB-F

0
100
200
300
400
469 a.a.

蛋白主名

其他名称

tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

ARL5B antisense RNA 1

NSUN6 抗体

目录号	产品名	应用	反应物种
HY-P86993	NSUN6 Antibody (YA6686)	WB	Human, Mouse, Rat

关联疾病

疾病名称

别名

Dubowitz Syndrome

Dubowitz'S Syndrome	Dwarfism-Eczema-Peculiar Facies Syndrome
Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09605	NSUN6 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22694	Nsun6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS29208	Nsun6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NSUN6	VGNC	VGNC:43992
Bos taurus	NSUN6	VGNC	VGNC:32287
Mus musculus	NSUN6	MGD	MGI:1921705
Rattus norvegicus	NSUN6	RGD	RGD:1309535
Felis catus	NSUN6	VGNC	VGNC:63895
Macaca mulatta	NSUN6	VGNC	VGNC:75452

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NSUN6 - NOP2/Sun RNA methyltransferase 6 Gene

关于 NSUN6

功能概要

NSUN6 基因产物(5)

NSUN6 蛋白结构

NSUN6 抗体

关联疾病

直系同源

热门区域

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NSUN6 - NOP2/Sun RNA methyltransferase 6 Gene

关于 NSUN6

功能概要

NSUN6 基因产物(5)

NSUN6 蛋白结构

NSUN6 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

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J

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N

Q

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