2. Gene
  3. GPRC6A - G protein-coupled receptor class C group 6 member A Gene

GPRC6A - G protein-coupled receptor class C group 6 member A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 C 类组 6 成员 A

种属: Homo sapiens

同用名: GPCR; bA86F4.3

基因 ID: 222545 | 基因类型: protein coding

关于 GPRC6A

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:116,792,085-116,829,240 (from NCBI)

This gene has 3 transcripts (splice variants), 218 orthologues and 4 paralogues. Low expression observed in reference dataset.

功能概要

蛋白偶联受体 (GPCR) 超家族的 C 家族成员，例如 GPRC6A，其特征在于与膜内 7 跨膜环区域相连的进化上保守的氨基酸感应基序。 GPCR C 家族的几个成员，包括 GPRC6A，也有一个长的 N 末端结构域 (Pi 等人总结，2005 [PubMed 16199532]) 。[OMIM 提供，2010 年 11 月]

Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

GPRC6A 基因产物(3)

mRNA Protein Name
NM_001286354.1 NP_001273283.1 G-protein coupled receptor family C group 6 member A isoform 2 precursor
NM_001286355.1 NP_001273284.1 G-protein coupled receptor family C group 6 member A isoform 3 precursor
NM_148963.4 NP_683766.2 G-protein coupled receptor family C group 6 member A isoform 1 precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to amino acid IDA
IDA: 通过直接分析推断
17478059 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPRC6A 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (75 - 479)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (519 - 571)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (603 - 837)

  • 0
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  • 926 a.a.
蛋白主名 其他名称

G-protein coupled receptor family C group 6 member A

G protein-coupled receptor, family C, group 6, member A

关联疾病

疾病名称 别名
Hyperparathyroidism

Hyperparathyroidism And Other Disorders Of Parathyroid Gland

Parathyroid Hyperfunction

Hpth - [Hyperparathyroidism]

Parathyroid Gland Hyperfunction

Parathyroid Glandular Hyperfunction
Ocular Albinism

Albinism, Ocular

Oa

Xloa

Albinism Ocular
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114165 DJ-V-159 Agonist 99.94% 否
HY-P10413 SHBG(141–161) Agonist / 否
HY-RS05753 GPRC6A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19062 Gprc6a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25552 Gprc6a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GPRC6A VGNC VGNC:41452
Macaca mulatta GPRC6A VGNC VGNC:72965
Felis catus GPRC6A VGNC VGNC:102433
Rattus norvegicus GPRC6A RGD RGD:735077
Mus musculus GPRC6A MGD MGI:2429498
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