2. Gene
  3. Atrx - ATRX, chromatin remodeler Gene

Atrx - ATRX, chromatin remodeler Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: XH2; Xnp; ATR2; MRXS3; Rad54; Hp1bp2; RAD54L; ZNF-HX; Hp1bp38; HP1-BP38; DXHXS6677E; 4833408C14Rik

基因 ID: 22589 | 基因类型: protein coding

关于 Atrx

功能概要

Enables chromatin binding activity and histone binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to hydroxyurea; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within several processes, including male gonad development; meiotic spindle organization; and post-embryonic forelimb morphogenesis. Located in PML body and chromosome. Is expressed in several structures, including alimentary system; early embryo; egg cylinder; genitourinary system; and nervous system. Used to study alpha thalassemia-X-linked intellectual disability syndrome. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Apr 2022]

Atrx 基因产物(1)

mRNA Protein Name
NM_009530.2 NP_033556.2 transcriptional regulator ATRX
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
15522233 MGI
enables histone binding IDA
IDA: 通过直接分析推断
20211137 MGI
enables histone binding IPI
IPI: 通过物理相互作用推断
20110566 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8978696 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
24651726 MGI
acts upstream of or within Sertoli cell development IMP
IMP: 通过突变表型推断
21427128 MGI
involved in cellular response to hydroxyurea IMP
IMP: 通过突变表型推断
24651726 MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle IMP
IMP: 通过突变表型推断
15242786 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
15668733 MGI
acts upstream of or within meiotic spindle organization IMP
IMP: 通过突变表型推断
15242786 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
24386478 MGI
involved in positive regulation of nuclear cell cycle DNA replication IMP
IMP: 通过突变表型推断
24651726 MGI
involved in positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
20110566 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
21427128 MGI
acts upstream of or within post-embryonic forelimb morphogenesis IMP
IMP: 通过突变表型推断
24386478 MGI
involved in protein localization to chromosome, telomeric region IMP
IMP: 通过突变表型推断
20110566 MGI
involved in replication fork processing IMP
IMP: 通过突变表型推断
24651726 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: 通过突变表型推断
21427128 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
21427128 MGI
involved in subtelomeric heterochromatin formation IMP
IMP: 通过突变表型推断
20211137 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
21427128 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
23444137 MGI
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
23444137 MGI
located in chromosome, telomeric region IDA
IDA: 通过直接分析推断
20110566 MGI
located in condensed chromosome, centromeric region IDA
IDA: 通过直接分析推断
15242786 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
14519686 MGI
located in nuclear chromosome IDA
IDA: 通过直接分析推断
11555636 MGI
located in nucleus IDA
IDA: 通过直接分析推断
17296936 MGI
located in pericentric heterochromatin IDA
IDA: 通过直接分析推断
15242786 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcriptional regulator ATRX

ATP-dependent helicase ATRX

HP1 alpha-interacting protein

X-linked nuclear protein

heterochromatin protein 2

Atrx 抗体

目录号 产品名 应用 反应物种
HY-P80004 Adiponectin Antibody (YA639) WB, ICC/IF, IHC-P Mouse
HY-P80024 ATRX Antibody (YA828) ICC/IF, IHC-P Mouse

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01252 ATRX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19577 Atrx Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26074 Atrx Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atrx NCBI NCBI:546
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