2. Gene
  3. Lrp4 - low density lipoprotein receptor-related protein 4 Gene

Lrp4 - low density lipoprotein receptor-related protein 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mdig; Megf7; D230026E03; 6430526J12Rik

基因 ID: 228357 | 基因类型: protein coding

关于 Lrp4

功能概要

Enables protein homodimerization activity and receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of presynaptic membrane organization; positive regulation of skeletal muscle acetylcholine-gated channel clustering; and synapse organization. Acts upstream of or within several processes, including animal organ development; embryonic digit morphogenesis; and regionalization. Located in neuromuscular junction and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; eye; and genitourinary system. Used to study sclerosteosis 2. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Lrp4 基因产物(2)

mRNA Protein Name
NM_001145857.1 NP_001139329.1 low-density lipoprotein receptor-related protein 4 isoform 2 precursor
NM_172668.3 NP_766256.3 low-density lipoprotein receptor-related protein 4 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coreceptor activity IDA
IDA: 通过直接分析推断
18848351 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18848351 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
18848351 MGI
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
18848351 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway IDA
IDA: 通过直接分析推断
16207730 MGI
acts upstream of or within anatomical structure development IMP
IMP: 通过突变表型推断
17119023 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: 通过突变表型推断
16207730 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
16517118 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
16207730 MGI
involved in enzyme-linked receptor protein signaling pathway IDA
IDA: 通过直接分析推断
18848351 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: 通过遗传相互作用推断
8653787 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: 通过突变表型推断
14622576 MGI
acts upstream of or within hair follicle development IMP
IMP: 通过突变表型推断
17119023 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
17119023 MGI
involved in negative regulation of axonogenesis IMP
IMP: 通过突变表型推断
22854782 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
20383322 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
20383322 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: 通过突变表型推断
17119023 MGI
involved in positive regulation of Rac protein signal transduction IDA
IDA: 通过直接分析推断
18848351 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
18957220 MGI
involved in positive regulation of presynaptic membrane organization IDA
IDA: 通过直接分析推断
22854782 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: 通过直接分析推断
18848351 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: 通过遗传相互作用推断
8653787 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
14622576 MGI
involved in postsynaptic membrane assembly IMP
IMP: 通过突变表型推断
22038977 MGI
involved in presynaptic membrane assembly IMP
IMP: 通过突变表型推断
22038977 MGI
acts upstream of or within protein localization IMP
IMP: 通过突变表型推断
17119023 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: 通过突变表型推断
17119023 MGI
acts upstream of or within receptor clustering IMP
IMP: 通过突变表型推断
17119023 MGI
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
25407677 MGI
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
25407677 MGI
involved in regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18848351 MGI
involved in skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
22038977 MGI
involved in synaptic assembly at neuromuscular junction IDA
IDA: 通过直接分析推断
18957220 MGI
acts upstream of or within synaptic assembly at neuromuscular junction IMP
IMP: 通过突变表型推断
17119023 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuromuscular junction IDA
IDA: 通过直接分析推断
18957220 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16263759 MGI
is active in synapse IDA
IDA: 通过直接分析推断
25407677 MGI
is active in synapse IEP
IEP: 通过表达模式推断
25407677 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

low-density lipoprotein receptor-related protein 4

LDLR dan

LRP-4

Lrp4 抗体

目录号 产品名 应用 反应物种
HY-P86948 LRP4 Antibody (YA6641) WB Mouse, Rat

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03047 CORIN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07799 LRP4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17975 Corin Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19911 Lrp4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26412 Lrp4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lrp4 NCBI NCBI:4038
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