SEPHS2 - selenophosphate synthetase 2 Gene

中文名称：硒磷酸合成酶 2

种属: Homo sapiens

同用名: SPS2

关于 SEPHS2

功能概要

该基因编码的酶可催化硒化物和 ATP 产生单硒磷酸 (MSP) 。 MSP 是合成硒代半胱氨酸 (Sec) 所需的硒供体，硒代半胱氨酸 (Sec) 在通常发出翻译终止信号的框内 UGA 密码子处共翻译并入硒蛋白。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，即 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。这种蛋白质本身是一种硒蛋白，在其活性位点含有一个 Sec 残基，表明存在一种自动调节机制。它优先在涉及硒蛋白合成的组织和血细胞发育部位表达。已在 5 号染色体上鉴定出该基因座的假基因。[RefSeq 提供，2017 年 5 月]

This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]