2. Gene
  3. ANGEL1 - angel homolog 1 Gene

ANGEL1 - angel homolog 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：天使同系物 1

种属: Homo sapiens

同用名: Ccr4e; KIAA0759

基因 ID: 23357 | 基因类型: protein coding

关于 ANGEL1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:76,786,009-76,812,882 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 5 paralogues. Broad expression in testis (RPKM 25.2), spleen (RPKM 10.7) and 25 other tissues.

功能概要

启用真核起始因子 4E 结合活性和蛋白质结构域特异性结合活性。预计参与 RNA 磷酸二酯键水解、核酸外切。位于多个细胞组件中，包括顺式高尔基网络；内质网；和细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANGEL1 基因产物(4)

mRNA Protein Name
NM_001370746.1 NP_001357675.1 protein angel homolog 1 isoform 1 precursor
NM_001370747.1 NP_001357676.1 protein angel homolog 1 isoform 2 precursor
NM_001370748.1 NP_001357677.1 protein angel homolog 1 isoform 3 precursor
NM_015305.4 NP_056120.2 protein angel homolog 1 isoform 4 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables eukaryotic initiation factor 4E binding IDA
IDA: 通过直接分析推断
23814182 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
31413325 GOA
enables protein domain specific binding IDA
IDA: 通过直接分析推断
23814182 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cis-Golgi network IDA
IDA: 通过直接分析推断
23814182 GOA
located in cytosol IDA
IDA: 通过直接分析推断
23814182 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23814182 GOA
is active in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
36180430 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23814182 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
23814182 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANGEL1 蛋白结构

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (248 - 619)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
蛋白主名 其他名称

protein angel homolog 1

关联疾病

疾病名称 别名
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9

Arrhythmogenic Right Ventricular Dysplasia 9

ARVD9

Arrhythmogenic Right Ventricular Cardiomyopathy 9

Arvc9

Familial Arrhythmogenic Right Ventricular Dysplasia 9

Dysplasia, Arrhythmogenic Right Ventricular, Type 9
Cranioectodermal Dysplasia 1

Sensenbrenner Syndrome

CED1

Levin Syndrome I

Cranio-Ectodermal Dysplasia

Dysplasia, Cranioectodermal, Type 1

Cranioectodermal Dysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00685 ANGEL1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ANGEL1 VGNC VGNC:59778
Bos taurus ANGEL1 VGNC VGNC:25886
Macaca mulatta ANGEL1 VGNC VGNC:69639
Rattus norvegicus ANGEL1 RGD RGD:1306238
Canis familiaris ANGEL1 VGNC VGNC:37852
Mus musculus ANGEL1 MGD MGI:1915987
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