2. Gene
  3. Scn3b - sodium channel, voltage-gated, type III, beta Gene

Scn3b - sodium channel, voltage-gated, type III, beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Scnb3; 1110001K16Rik; 4833414B02Rik

基因 ID: 235281 | 基因类型: protein coding

关于 Scn3b

功能概要

Enables transmembrane transporter binding activity and voltage-gated Sodium Channel activity involved in cardiac muscle cell action potential. Involved in SA node cell action potential; positive regulation of heart rate; and regulation of atrial cardiac muscle cell membrane depolarization. Acts upstream of or within cardiac conduction and ventricular cardiac muscle cell action potential. Located in Z disc. Is expressed in several structures, including gut; nervous system; sensory organ; skeletal musculature; and urinary system. Used to study Brugada syndrome 7. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Scn3b 基因产物(4)

mRNA Protein Name
NM_001083917.1 NP_001077386.1 sodium channel subunit beta-3 isoform a precursor
NM_001286614.1 NP_001273543.1 sodium channel subunit beta-3 isoform b
NM_001359700.1 NP_001346629.1 sodium channel subunit beta-3 isoform a precursor
NM_178227.4 NP_839941.1 sodium channel subunit beta-3 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
20042427 MGI
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
19351516 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SA node cell action potential IMP
IMP: 通过突变表型推断
19796257 MGI
acts upstream of or within cardiac conduction IMP
IMP: 通过突变表型推断
19351516 MGI
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
19796257 MGI
involved in regulation of atrial cardiac muscle cell membrane depolarization IMP
IMP: 通过突变表型推断
19796257 MGI
acts upstream of or within ventricular cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
19351516 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
17884088 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sodium channel subunit beta-3

brain and heart sodium channel beta 3 subunit

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12536 SCN3B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21042 Scn3b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27560 Scn3b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scn3b NCBI NCBI:55800
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