2. Gene
  3. Atp1a2 - ATPase Na+/K+ transporting subunit alpha 2 Gene

Atp1a2 - ATPase Na+/K+ transporting subunit alpha 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RATATPA2

基因 ID: 24212 | 基因类型: protein coding

关于 Atp1a2

功能概要

Enables several functions, including ATP binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in several processes, including cation transport; cellular response to mechanical stimulus; and negative regulation of calcium:sodium antiporter activity. Located in several cellular components, including T-tubule; caveola; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a2 基因产物(1)

mRNA Protein Name
NM_012505.2 NP_036637.1 sodium/potassium-transporting ATPase subunit alpha-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IMP
IMP: 通过突变表型推断
12529322 RGD
enables ATPase-coupled monoatomic cation transmembrane transporter activity IMP
IMP: 通过突变表型推断
12529322 RGD
enables P-type sodium:potassium-exchanging transporter activity IDA
IDA: 通过直接分析推断
16624992 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12093728 RGD
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
28787093 RGD
enables steroid hormone binding IDA
IDA: 通过直接分析推断
17442282 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IDA
IDA: 通过直接分析推断
17458903 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
16893515 RGD
involved in cellular response to steroid hormone stimulus IMP
IMP: 通过突变表型推断
17442282 RGD
involved in negative regulation of calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
17442282 RGD
involved in negative regulation of calcium:sodium antiporter activity IMP
IMP: 通过突变表型推断
17442282 RGD
involved in potassium ion transport IDA
IDA: 通过直接分析推断
12093728 RGD
involved in proton transmembrane transport IMP
IMP: 通过突变表型推断
12529322 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: 通过突变表型推断
17442282 RGD
involved in response to glycoside IMP
IMP: 通过突变表型推断
17442282 RGD
involved in response to nicotine IDA
IDA: 通过直接分析推断
22442718 RGD
involved in sodium ion transport IDA
IDA: 通过直接分析推断
12093728 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
17442282 RGD
located in caveola IDA
IDA: 通过直接分析推断
16624992 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
11950769 RGD
located in endosome IDA
IDA: 通过直接分析推断
16893515 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
17442282 RGD
located in membrane IDA
IDA: 通过直接分析推断
28787093 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
17442282 RGD
part of sodium:potassium-exchanging ATPase complex IDA
IDA: 通过直接分析推断
12093728 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sodium/potassium-transporting ATPase subunit alpha-2

ATPase, Na+/K+ transporting, alpha 2 polypeptide

ATPase, Na+K+ transporting, alpha 2

Na(+)/K(+) ATPase alpha(+) subunit

Na(+)/K(+) ATPase alpha-2 subunit

Na+/K+ -ATPase alpha 2 subunit

sodium pump subunit alpha-2

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01183 ATP1A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01187 ATP1B2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21822 Atp1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21823 Atp1b2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28339 Atp1a2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atp1a2 NCBI NCBI:477
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