2. Gene
  3. Atp7b - ATPase copper transporting beta Gene

Atp7b - ATPase copper transporting beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Wd; Hts; PINA

基因 ID: 24218 | 基因类型: protein coding

关于 Atp7b

功能概要

Enables copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Located in several cellular components, including basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Used to study Wilson disease; hepatitis; hepatocellular carcinoma; liver carcinoma; and renal adenoma. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Apr 2022]

Atp7b 基因产物(1)

mRNA Protein Name
NM_012511.2 NP_036643.2 copper-transporting ATPase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables copper ion binding IDA
IDA: 通过直接分析推断
14732483 RGD
enables copper ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9920665 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
14732483 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to copper ion IEP
IEP: 通过表达模式推断
24614235 RGD
involved in cellular response to copper ion IMP
IMP: 通过突变表型推断
24614235 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
24614235 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
9920665 RGD
involved in copper ion export IMP
IMP: 通过突变表型推断
24614235 RGD
involved in lactation IEP
IEP: 通过表达模式推断
16741141 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
9920665 RGD
involved in response to copper ion IEP
IEP: 通过表达模式推断
15591161 RGD
involved in response to prolactin IEP
IEP: 通过表达模式推断
16741141 RGD
involved in response to zinc ion IEP
IEP: 通过表达模式推断
12840169 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
15994426 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
24614235 RGD
located in bicellular tight junction IDA
IDA: 通过直接分析推断
18395099 RGD
located in late endosome IDA
IDA: 通过直接分析推断
16741141 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
24614235 RGD
located in tight junction IDA
IDA: 通过直接分析推断
18395099 RGD
located in trans-Golgi network IDA
IDA: 通过直接分析推断
15994426 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

copper-transporting ATPase 2

ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)

PINA gene, promoter

copper pump 2

pineal night-specific ATPase

wilson disease-associated protein homolog

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01236 ATP7B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17601 Atp7b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24061 Atp7b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atp7b NCBI NCBI:540
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