2. Gene
  3. NES - Nes nestin Gene

NES - Nes nestin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 25491 | 基因类型: protein coding

关于 NES

功能概要

Enables CCR5 Chemokine Receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Apr 2022]

NES 基因产物(2)

mRNA Protein Name
NM_001308239.1 NP_001295168.1 nestin isoform 1
NM_012987.2 NP_037119.2 nestin isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CCR5 chemokine receptor binding IPI
IPI: 通过物理相互作用推断
19559698 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of intermediate filament depolymerization IDA
IDA: 通过直接分析推断
12686602 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
20510364 RGD
involved in response to ionizing radiation IEP
IEP: 通过表达模式推断
12445635 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
17065391 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17510525 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in intermediate filament IDA
IDA: 通过直接分析推断
12832492 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nestin

相关产品

Approval
生物活性分子 (16)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0193A Prazosin hydrochloride 99.51% 否
HY-122272 Paroxetine Inhibitor 99.92% 是
HY-B0527 Amitriptyline 99.94% 是
HY-B0527A Amitriptyline hydrochloride 99.94% 是
HY-B0196 Venlafaxine Inhibitor 99.71% 是
HY-17385 Atomoxetine hydrochloride Inhibitor 99.91% 是
HY-B0196A Venlafaxine hydrochloride Inhibitor 99.76% 是
HY-B1110 Nomifensine Inhibitor 98.93% 否
HY-B1110A Nomifensine maleate Inhibitor 98.73% 否
HY-W380450 Viloxazine 99.15% 否
HY-125784 Viloxazine hydrochloride Inhibitor 98.94% 否
HY-B0527AR Amitriptyline hydrochloride (Standard) 99.03% 否
HY-B0196AR Venlafaxine hydrochloride (Standard) Inhibitor 99.99% 否
HY-107370 Atomoxetine Inhibitor / 否
HY-B0193AR Prazosin hydrochloride (Standard) / 否
HY-B0773 Paroxetine mesylate Inhibitor / 否
Clinical Phase
生物活性分子 (14)
目录号 产品名 作用方式
纯度 Phase
HY-16736A Centanafadine hydrochloride Inhibitor 99.55% Phase 3
HY-18600A Azimilide dihydrochloride Inhibitor 98.17% Phase 3
HY-18600 Azimilide Inhibitor 99.01% Phase 3
HY-119541A Ampreloxetine TFA 98.30% Phase 3
HY-106865 Mivazerol / Phase 3
HY-16736 Centanafadine Inhibitor 99.62% Phase 3
HY-15651 Alvelestat Inhibitor 99.87% Phase 2
HY-108039 Bezisterim Inhibitor 95.0% Phase 2
HY-14472 Tesofensine Inhibitor 99.31% Phase 2
HY-U00256 ZD8321 Inhibitor ≥95.0% Phase 2
HY-15793 NBI-98782 Inhibitor 98.56% Phase 1
HY-101607 KT-362 Antagonist / Phase 1
HY-123044 Tedatioxetine Antagonist / Phase 1
HY-145487A 5-Hydroxy-6-methoxy (S)-duloxetine maleate Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (80)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101784 NE 52-QQ57 99.89% 否
HY-N0740 Jatrorrhizine chloride Inhibitor 99.82% 否
HY-78932A Dap-NE hydrochloride 99.99% 否
HY-101484A NE-100 hydrochloride 99.1% 否
HY-78931 Boc-Dap-NE 99.96% 否
HY-16011 NE 10790 Inhibitor 99.50% 否
HY-101323 Olvanil Agonist ≥99.0% 否
HY-N0749A Jatrorrhizine hydroxide Inhibitor 98.06% 否
HY-W008794S Normetanephrine-d3 hydrochloride 99.62% 否
HY-119541 Ampreloxetine Inhibitor 98.49% 是
HY-B0196AS1 Venlafaxine-d6 hydrochloride Inhibitor 98.18% 否
HY-W008794 Normetanephrine hydrochloride 99.69% 否
HY-B0527AS Amitriptyline-d6 hydrochloride 99.65% 否
HY-B0196S Venlafaxine-d6 Inhibitor 98.55% 否
HY-78931A (R,S,S,R,S)-Boc-Dap-NE 97.13% 否
HY-N1745 2'-O-Methylisoliquiritigenin Activator 99.06% 否
HY-78932G Dap-NE hydrochloride (GMP) / 否
HY-101755 Tedatioxetine hydrobromide Antagonist 99.83% 否
HY-106823 Tebufelone Inhibitor 99.52% 否
HY-14794 Dextromilnacipran Inhibitor 99.90% 否
HY-N0749 Jatrorrhizine Inhibitor / 否
HY-W112651 2,4,6-Triphenylaniline Inhibitor 95.0% 否
HY-W417914 4-Methylamphetamine hydrochloride Agonist 99.86% 否
HY-132132 Neutrophil elastase inhibitor 3 Inhibitor 97.23% 否
HY-78931B (S,S,S,S,R)-Boc-Dap-NE / 否
HY-78931C (S,S,R,S,R)-Boc-Dap-NE / 否
HY-78931E (R,S,R,S,R)-Boc-Dap-NE / 否
HY-78931F (R,S,S,S,R)-Boc-Dap-NE / 否
HY-78932 Dap-NE 99.49% 否
HY-78932C (2S,3R)-Dap-NE hydrochloride Inhibitor / 否
HY-78931G Boc-Dap-NE (GMP) / 否
HY-15651A Alvelestat tosylate Inhibitor / 否
HY-B1110S Nomifensine-d3 maleate Inhibitor / 否
HY-101607A KT-362 free acid Antagonist / 否
HY-103247 EMD 66684 Antagonist / 否
HY-105330 SIB 1663 Agonist / 否
HY-107562 JNJ 10181457 dihydrochloride Antagonist / 否
HY-111124 Paroxetine-d2 / 否
HY-113933 NE11808 / 否
HY-118064 (R)-Thionisoxetine / 否
HY-118064A (R)-Thionisoxetine hydrochloride / 否
HY-122272S2 Paroxetine-d6-1 Inhibitor / 否
HY-122300A Oxaprotiline Inhibitor / 否
HY-126825 NE21650 Inhibitor / 否
HY-12711 2-Methoxyidazoxan Antagonist / 否
HY-129305 Tampramine fumarate Inhibitor / 否
HY-129985 Clovoxamine Inhibitor / 否
HY-131284 (S)-Dehydro Venlafaxine / 否
HY-136860 (R)-Venlafaxine Inhibitor / 否
HY-138257 (S)-Indeloxazine benzenesulfonate Inhibitor / 否
HY-144123 HIV-1 inhibitor-16 Inhibitor / 否
HY-144246S Zofenoprilat-NES-d5 / 否
HY-14794S Dextromilnacipran-d6 / 否
HY-17032A Indeloxazine hydrochloride Inhibitor / 否
HY-172996 NNRT-IN-8 Inhibitor / 否
HY-18600AS Azimilide-d8 dihydrochloride Inhibitor / 否
HY-B0196B (S)-Venlafaxine Inhibitor / 否
HY-B0196S1 Venlafaxine-d6-1 Inhibitor / 否
HY-B0196S4 Venlafaxine-d9 / 否
HY-N6847 5,​6,​7,​40-​Tetrahydroxyisoflavo​ne-​6,​7-​di-​o-​b-​D-​glucopyranoside / 否
HY-P10435 KEMPFPKYPVEP Agonist / 否
HY-P3064 Scyllatoxin Antagonist / 否
HY-P3648 Ala-Ala-Pro-Val-chloromethylketone Inhibitor / 否
HY-RS09211 NES Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W061043 DOV-216,303 Inhibitor / 否
HY-W681014 5-Fluoro-α-methyltryptamine hydrochloride Activator / 否
HY-W700149 N,O-Didesmethylvenlafaxine-d3 / 否
HY-107370S Atomoxetine-d7 Inhibitor / 否
HY-107370S1 Atomoxetine-d5 / 否
HY-11046A KRP-109 / 否
HY-117012 NE58018 / 否
HY-122272S Paroxetine-d4 Inhibitor / 否
HY-138257A (R)-Indeloxazine benzenesulfonate Inhibitor / 否
HY-138818 N,O-Didesmethylvenlafaxine / 否
HY-78932D (2R,3R)-Dap-NE hydrochloride Inhibitor / 否
HY-B0196AS Venlafaxine-d10 hydrochloride Inhibitor / 否
HY-B0196S2 Venlafaxine-d4 Inhibitor / 否
HY-B0196S3 Venlafaxine-d10 Inhibitor / 否
HY-RS17729 Nes Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24194 Nes Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens NES NCBI NCBI:10763
Macaca fascicularis NES NCBI NCBI:102136783
Mus musculus NES NCBI NCBI:18008
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