1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Scyllatoxin

Scyllatoxin  (Synonyms: Leiurotoxin I)

目录号: HY-P3064
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Scyllatoxin (Leiurotoxin I) 是一种肽毒素,它可以从毒蝎 (Leiurus quinquestriatus hebraeus) 的毒液中分离出来。Scyllatoxin 是小电导钙激活型钾通道 KCa (SK) 的阻断剂。Scyllatoxin 能够增强体内去甲肾上腺素 (NE) 和肾上腺素 (Epi) 的释放。

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Custom Peptide Synthesis

Scyllatoxin Chemical Structure

Scyllatoxin Chemical Structure

CAS No. : 142948-19-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].

体外研究
(In Vitro)

For scyllatoxin, the Arg6 and Arg13 are essential for binding to the Ca2+-activated K+ channel protein and for the functional effect of the toxin[1].
For scyllatoxin, His31 is important for the binding activity of the toxin and for the induction of contractions on taenia coli[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Scyllatoxin (2 μM) increases basal Epi release, the nerve stimulation-induced Epi release and the exogenous acetylcholine (Ach)-induced catecholamine release by microdialysis technique to the left adrenal medulla of anesthetized adult male Wistar rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3423.15

Formula

C142H237N45O39S7

CAS 号
Sequence Shortening

AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge: Cys3-Cys21; Cys8-Cys26; Cys12-Cys28)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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