2. Gene
  3. Hnf4a - hepatocyte nuclear factor 4, alpha Gene

Hnf4a - hepatocyte nuclear factor 4, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Hnf4; Hnf4alpha

基因 ID: 25735 | 基因类型: protein coding

关于 Hnf4a

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; long-chain fatty acid binding activity; and long-chain fatty acyl-CoA binding activity. Involved in several processes, including hepatocyte differentiation; negative regulation of peptidyl-tyrosine phosphorylation; and regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Biomarker of hepatocellular carcinoma and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hnf4a 基因产物(3)

mRNA Protein Name
NM_001270931.1 NP_001257860.1 hepatocyte nuclear factor 4-alpha isoform 2
NM_001270933.1 NP_001257862.1 hepatocyte nuclear factor 4-alpha isoform 3
NM_022180.2 NP_071516.2 hepatocyte nuclear factor 4-alpha isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20735474 RGD
enables arachidonate binding IDA
IDA: 通过直接分析推断
11940586 RGD
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16640558 RGD
enables fatty acid binding IPI
IPI: 通过物理相互作用推断
15870076 RGD
enables fatty-acyl-CoA binding IPI
IPI: 通过物理相互作用推断
15870076 RGD
enables long-chain fatty acyl-CoA binding IDA
IDA: 通过直接分析推断
11940586 RGD
enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: 通过直接分析推断
15870076 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
14530276 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
12205093 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
12205093 RGD
enables protein-containing complex binding IMP
IMP: 通过突变表型推断
2279702 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
12089346 RGD
enables sequence-specific DNA binding IMP
IMP: 通过突变表型推断
16893891 RGD
enables stearic acid binding IDA
IDA: 通过直接分析推断
11940586 RGD
enables transcription coregulator binding IPI
IPI: 通过物理相互作用推断
19651776 RGD
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
12205093 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acyl-CoA metabolic process IDA
IDA: 通过直接分析推断
15870076 RGD
involved in cell differentiation IMP
IMP: 通过突变表型推断
16563856 RGD
involved in cell-cell junction organization IDA
IDA: 通过直接分析推断
12749857 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
24177414 RGD
involved in establishment of tissue polarity IDA
IDA: 通过直接分析推断
12749857 RGD
involved in hepatocyte differentiation IEP
IEP: 通过表达模式推断
19621519 RGD
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
16584384 RGD
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
12036449 RGD
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15541721 RGD
involved in negative regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
15541721 RGD
involved in negative regulation of non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
16584384 RGD
involved in negative regulation of protein import into nucleus IDA
IDA: 通过直接分析推断
16584384 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19651776 RGD
involved in positive regulation of fatty acid biosynthetic process IMP
IMP: 通过突变表型推断
16800817 RGD
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
12089346 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
12205093 RGD
involved in positive regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
16893891 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20735474 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16893891 RGD
involved in regulation of microvillus assembly IMP
IMP: 通过突变表型推断
17178913 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
16799975 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
16570165 RGD
involved in response to glucose IDA
IDA: 通过直接分析推断
16800817 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
11679969 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
17640976 RGD
involved in response to trichostatin A IDA
IDA: 通过直接分析推断
12205093 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16799975 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
19651776 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepatocyte nuclear factor 4-alpha

HNF-4-alpha

TCF-14

alpha transcription factor 4

hepatic nuclear factor 4, alpha

nuclear receptor subfamily 2 group A member 1

transcription factor 14

transcription factor HNF-4

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06257 HNF4A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17608 Hnf4a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-176847 HNF4A-IN-1 / 否
HY-RS06255 HNF1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174669 Human HNF1A mRNA / 否
HY-RS24068 Hnf4a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hnf4a NCBI NCBI:3172
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