AOC1 - amine oxidase copper containing 1 Gene

中文名称：含铜胺氧化酶 1

种属: Homo sapiens

同用名: ABP; DAO; KAO; ABP1; DAO1

基因 ID: 26 | 基因类型: protein coding

关于 AOC1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,852,120-150,861,504 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and 2 paralogues. Biased expression in placenta (RPKM 229.3), kidney (RPKM 118.3) and 3 other tissues.

功能概要

该基因编码一种金属结合膜糖蛋白，可使腐胺、组胺和相关化合物氧化脱氨。编码的蛋白质被阿米洛利抑制，阿米洛利是一种通过关闭上皮钠离子通道起作用的利尿剂。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2013 年 1 月]

This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

AOC1 基因产物(2)

mRNA	Protein	Name
NM_001091.4	NP_001082.2	amiloride-sensitive amine oxidase [copper-containing] isoform 2 precursor
NM_001272072.2	NP_001259001.1	amiloride-sensitive amine oxidase [copper-containing] isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	IDA IDA: 通过直接分析推断	12072962	GOA
enables copper ion binding	IDA IDA: 通过直接分析推断	12072962	GOA
enables diamine oxidase activity	IDA IDA: 通过直接分析推断	8144586	GOA
enables heparin binding	IDA IDA: 通过直接分析推断	19764817	GOA
enables histamine oxidase activity	IDA IDA: 通过直接分析推断	12072962	GOA
enables primary methylamine oxidase activity	IDA IDA: 通过直接分析推断	8144586	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	19764817	GOA
enables putrescine oxidase activity	IDA IDA: 通过直接分析推断	7626074	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in putrescine metabolic process	IMP IMP: 通过突变表型推断	8144586	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular exosome	IDA IDA: 通过直接分析推断	21082674	GOA
is active in extracellular space	IDA IDA: 通过直接分析推断	8144586	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	9399025	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	2217167	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AOC1 蛋白结构

Cu_amine_oxidN2

Cu_amine_oxidN3

Cu_amine_oxid

0
200
400
600
751 a.a.

蛋白主名

其他名称

amiloride-sensitive amine oxidase [copper-containing]

amiloride binding protein 1 (amine oxidase (copper-containing))

AOC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AOC1	P19801	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
种属内	AOC1	P19801	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
种属内	AOC1	P19801	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
种属内	AOC1	P19801	TIAL1	Homo sapiens	Q01085-2	Validated Y2H	32296183
种属内	AOC1	P19801	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
种属内	AOC1	P19801	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
种属内	AOC1	P19801	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
种属内	AOC1	P19801	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 AOC1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7497	ABP1/AOC1 Protein, Human (HEK293, His)	AAH14093.1 (E20-V751)	≥95%

关联疾病

疾病名称

别名

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Trimethoprim Allergy

Primsol Allergy	Proloprim Allergy
Tmp Allergy

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Intestinal Disease

Intestinal Diseases

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal

Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia

Rhinitis

Runny Nose

Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Proctitis

Ulcerative Proctitis	Chronic Ulcerative Proctitis
Idiopathic Proctitis	Nonspecific Ulcerative Proctitis
Ulcerative Colitis Confined To Rectum	Ip - [Idiopathic Proctitis]
Chronic Ulcerative Proctitis Nos

Benign Ileal Neoplasm

Ileal Tumor	Ileal Neoplasms
Ileal Neoplasm

Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing

Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.	Acute Git Vascular Insuffic.
Acute Intestinal Ischemia	Acute Intestinal Vascular Insufficiency

Adermatoglyphia

ADERM	Immigration Delay Disease
Absence Of Fingerprints	Adg
Congenital Absence Of Fingerprints	Isolated Congenital Adermatoglyphia
Fingerprints, Absence Of	Skin Abnormalities

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-143721	SSAO inhibitor-2	Inhibitor	/	否
HY-143723	SSAO inhibitor-3	Inhibitor	/	否
HY-RS00771	AOC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17364	Aoc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23818	Aoc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	AOC1	RGD	RGD:61296
Macaca mulatta	AOC1	VGNC	VGNC:70033
Canis familiaris	AOC1	VGNC	VGNC:37947
Bos taurus	AOC1	VGNC	VGNC:25972
Felis catus	AOC1	VGNC	VGNC:68565
Mus musculus	AOC1	MGD	MGI:1923757
Others	AOC1	NCBI

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