2. Gene
  3. GLCE - glucuronic acid epimerase Gene

GLCE - glucuronic acid epimerase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：葡萄糖醛酸差向异构酶

种属: Homo sapiens

同用名: HSEPI

基因 ID: 26035 | 基因类型: protein coding

关于 GLCE

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,160,635-69,272,207 (from NCBI)

This gene has 4 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in colon (RPKM 5.9), duodenum (RPKM 5.7) and 25 other tissues.

功能概要

启用钙离子结合活性； heparosan-N-硫酸盐-葡萄糖醛酸盐 5-差向异构酶活性；和蛋白质同二聚化活性。参与硫酸乙酰肝素蛋白多糖的生物合成过程。预测位于高尔基体膜。预计是膜的组成部分。预测在高尔基体中活跃。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

GLCE 基因产物(5)

mRNA Protein Name
NM_001324091.2 NP_001311020.1 D-glucuronyl C5-epimerase isoform 2
NM_001324092.2 NP_001311021.1 D-glucuronyl C5-epimerase isoform 3
NM_001324093.2 NP_001311022.1 D-glucuronyl C5-epimerase isoform 1
NM_001324094.2 NP_001311023.1 D-glucuronyl C5-epimerase isoform 1
NM_015554.3 NP_056369.1 D-glucuronyl C5-epimerase isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
30872481 GOA
enables heparosan-N-sulfate-glucuronate 5-epimerase activity IDA
IDA: 通过直接分析推断
15853773 GOA
enables heparosan-N-sulfate-glucuronate 5-epimerase activity IMP
IMP: 通过突变表型推断
20118238 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
30872481 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: 通过直接分析推断
20118238 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLCE 蛋白结构

C5-epim_C

C5-epim_C: D-glucuronyl C5-epimerase C-terminus (416 - 607)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
蛋白主名 其他名称

D-glucuronyl C5-epimerase

UDP-glucuronic acid epimerase

关联疾病

疾病名称 别名
Triosephosphate Isomerase Deficiency

TPID

Triose Phosphate-Isomerase Deficiency

Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

Tpi Deficiency

Triose Phosphate Isomerase Deficiency

Deficiency Of Phosphotriose Isomerase

Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05467 GLCE Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GLCE MGD MGI:2136405
Rattus norvegicus GLCE RGD RGD:1565253
Macaca mulatta GLCE VGNC VGNC:72959
Canis familiaris GLCE VGNC VGNC:41251
Bos taurus GLCE VGNC VGNC:29394
Felis catus GLCE VGNC VGNC:62573
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