OPTC - opticin Gene

中文名称：视蛋白

种属: Homo sapiens

同用名: OPT

基因 ID: 26254 | 基因类型: protein coding

关于 OPTC

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,494,153-203,508,949 (from NCBI)

This gene has 2 transcripts (splice variants), 111 orthologues and 1 paralogue. Low expression observed in reference dataset.

功能概要

Opticin 属于富含亮氨酸的小重复蛋白 (SLRP) 家族的 III 类。该家族的成员通常与细胞外基质有关。视蛋白大量存在于眼睛的玻璃体中，并且还定位于角膜、虹膜、睫状体、视神经、脉络膜、视网膜和胎肝。 Opticin 可以非共价结合胶原纤维并调节纤维形态、间距和组织。 opticin 基因被映射到与遗传性眼病年龄相关性黄斑变性 (AMD) 和视网膜色素变性后柱共济失调 (AXPC1) 相关的 1 号染色体区域。[RefSeq 提供，2008 年 7 月]

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind Collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]

OPTC 基因产物(1)

mRNA	Protein	Name
NM_014359.4	NP_055174.1	opticin precursor

基因本体论

细胞组分

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular matrix	IDA IDA: 通过直接分析推断	18164633	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OPTC 蛋白结构

LRR_8

0
100
200
300
332 a.a.

蛋白主名

其他名称

opticin

oculoglycan

关联疾病

疾病名称

别名

Posterior Column Ataxia

Biemond Ataxia

Open-Angle Glaucoma

Glaucoma Simplex	Pigmentary Glaucoma
Wide-Angle Glaucoma	Glaucoma, Open-Angle
Open Angle Glaucoma	Glaucoma Open-Angle
Chronic Simple Glaucoma	Coag - [Chronic Open-Angle Glaucoma]
Csg - [Chronic Simple Glaucoma]	Poag - [Primary Open-Angle Glaucoma]
Oag - [Open-Angle Glaucoma]	Chronic Glaucoma
Chronic Open Angle Glaucoma	Simple Glaucoma
Chronic Noncongestive Glaucoma	Ltg - [Low Tension Glaucoma]
Noncongestive Glaucoma	Nonobstructive Glaucoma
Normal Pressure Glaucoma	Primary Low Tension Glaucoma
Low-Tension Glaucoma	Residual Stage Low Tension Glaucoma
Open Cleft Glaucoma

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Vitreous Detachment

Posterior Vitreous Detachment

Vitreous Syneresis

Vitreoretinal Dystrophy

Vitreoretinal Dystrophies

Retinal Perforation

Retinal Break	Retinal Perforations
Retinal Dialysis	Retinal Tear
Retinal Break Nos	Ruptured Retina

Vitreous Syneresis

Vitreous Degeneration

Vitreous Disease

Disorder Of Vitreous Body

Cornea Plana

Flat Cornea

Macular Holes

Macular Hole

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Optic Disk Drusen

Optic Disc Drusen	Drusen Of Optic Disc
Optic Nerve Head Drusen	Drusen Optic Disc

Glaucoma, Normal Tension

Low Tension Glaucoma	Glaucoma, Normal Tension, Susceptibility To
Normal Tension Glaucoma	Ntg
Glaucoma, Normal Pressure	NPG
Glaucoma, Normal Pressure, Susceptibility To	Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Stickler Syndrome

Arthroophthalmopathy	Hereditary Arthro-Ophthalmo-Dystrophy
Hereditary Arthro-Ophthalmopathy	Stickler Dysplasia
Hereditary Progressive Arthroophthalmopathy	Stickler Syndrome, Type 1

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09808	OPTC Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	OPTC	VGNC	VGNC:75590
Rattus norvegicus	OPTC	RGD	RGD:1304916
Felis catus	OPTC	VGNC	VGNC:68637
Mus musculus	OPTC	MGD	MGI:2151113
Canis familiaris	OPTC	VGNC	VGNC:44135
Bos taurus	OPTC	VGNC	VGNC:32441

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

OPTC - opticin Gene

关于 OPTC

功能概要

OPTC 基因产物(1)

OPTC 蛋白结构

关联疾病

直系同源

热门区域

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OPTC - opticin Gene

关于 OPTC

功能概要

OPTC 基因产物(1)

OPTC 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z