GDF2 - growth differentiation factor 2 Gene

中文名称：生长分化因子 2

种属: Homo sapiens

同用名: BMP9; HHT5; BMP-9

基因 ID: 2658 | 基因类型: protein coding

关于 GDF2

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:47,322,454-47,327,588 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues, 31 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 6.7).

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。这种蛋白质调节软骨和骨骼发育、血管生成和胆碱能中枢神经系统神经元的分化。该基因的突变与遗传性出血性毛细血管扩张症有关。[RefSeq 提供，2016 年 7 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016]

GDF2 基因产物(1)

mRNA	Protein	Name
NM_016204.4	NP_057288.1	growth/differentiation factor 2 preproprotein

GDF2 蛋白结构

TGFb_propeptide

TGF_beta

0
100
200
300
400
429 a.a.

蛋白主名

其他名称

growth/differentiation factor 2

bone morphogenetic protein 9

重组 GDF2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77880	BMP-9/GDF-2 Protein, Human (HEK293, Fc)	Q9UK05 (S320-R429)	≥95%
HY-P700033AF	Animal-Free BMP-9/GDF-2 Protein, Human (His)	Q9UK05 (S320-429R)	≥95%
HY-P700530	GDF-2 Protein, Human (P. pastoris, His)	Q9UK05 (H300-R429)	≥95%

关联疾病

疾病名称

别名

Telangiectasia, Hereditary Hemorrhagic, Type 5

HHT5	Telangiectasia, Hereditary Hemorrhagic, 5
Telangiectasia, Hemorrhagic, Hereditary, Type 5

Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease	Hht
Osler-Weber-Rendu Disease	Telangiectasia, Hereditary Hemorrhagic
Osler Hemorrhagic Telangiectasia Syndrome	Orw Disease
Osler Weber Rendu Syndrome	Osler-Rendu-Weber Disease
Osler-Weber-Rendu Syndrome	Rendu-Osler Disease
Telangiectasia Hereditary Hemorrhagic	Telangiectasia Hemorrhagic, Hereditary
Hht - [Hereditary Haemorrhagic Telangiectasia]	Osler Haemorrhagic Telangiectasia Syndrome

Pulmonary Hypertension, Primary, 1

Pulmonary Arterial Hypertension	Pah
Idiopathic Pulmonary Arterial Hypertension	Idiopathic Pulmonary Hypertension
Primary Pulmonary Hypertension	PPH1
Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated	Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht
Pph	Familial Primary Pulmonary Hypertension
Sporadic Primary Pulmonary Hypertension	Pht
Fpah	Familial Pulmonary Arterial Hypertension
Hereditary Pulmonary Arterial Hypertension	Heritable Pulmonary Arterial Hypertension
Ayerza Syndrome	Fpph
Ppht	Ipah
Primary Pulmonary Arterial Hypertension	Pulmonary Hypertension, Familial Primary
Hypertension, Pulmonary, Primary, Type 1	Ayerza'S Syndrome
Pah - [Pulmonary Arterial Hypertension]	Arrillaga Ayerza Syndrome

Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome

Juvenile Polyposis-Hereditary Hemorrhagic Telangiectasia Syndrome	JPHT
Jp/Hht Syndrome	Juvenile Polyposis With Hereditary Hemorrhagic Telangiectasia
Jps/Hht	Telangiectasia, Hereditary Hemorrhagic, With Juvenile Polyposis Coli
Polyposis, Generalized Juvenile, With Pulmonary Arteriovenous Malformation	Jp-Hht
JP/HHT	Polyposis, Juvenile/Hereditary Hemorrhagic Telangiectasia Syndrome

Hepatopulmonary Syndrome

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Arteriovenous Malformation

Arteriovenous Malformations	Arteriovenous Hemangioma
Cirsoid Aneurysm	Racemose Aneurysm
Racemose Angioma	Racemose Hemangioma
Congenital Arteriovenous Malformation

Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease	Obstructive Disease Of The Pulmonary Veins
Pvod	Isolated Pulmonary Venous Sclerosis
Venous Form Of Primary Pulmonary Hypertension	Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Telangiectasis

Telangiectasia

Cardiovascular Organ Benign Neoplasm

Ossification Of The Posterior Longitudinal Ligament Of Spine

OPLL	Ossification Of The Posterior Longitudinal Ligament Of The Spine
Ossification Of Posterior Longitudinal Ligament Of Spine	Ossification, Posterior Longitudinal Ligament Spine

Myostatin-Related Muscle Hypertrophy

Mslhp

Muscle Hypertrophy Syndrome

Ischiocoxopodopatellar Syndrome With Or Without Pulmonary Arterial Hypertension

Small Patella Syndrome	Ischiopatellar Dysplasia
Coxopodopatellar Syndrome	Scott-Taor Syndrome
Sps	Ischiocoxopodopatellar Syndrome
Patella Aplasia, Coxa Vara, And Tarsal Synostosis	ICPPS
Congenital Coxa Vara, Patella Aplasia And Tarsal Synostosis	Coxo-Podo-Patellar Syndrome
Patella Aplasia, Coxa Vara, Tarsal Synostosis	Coxopodipatellar Syndrome

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva	Progressive Myositis Ossificans
FOP	Progressive Ossifying Myositis
Myositis Ossificans	Stone Man Syndrome
Man Of Stone	Myositis Ossificans Progressive
Diffuse Progressive Ossifying Polymyositis	Fibrodysplasia Ossificans Congenita
Myositis Ossificans Progressiva, Site Unspecified	Münchmeyer Disease
Fop - [Fibrodysplasia Ossificans Progressiva]	Progressive Myositis Ossificans Calcification

Geotrichosis

Juvenile Polyposis Syndrome

JPS	Juvenile Intestinal Polyposis
Jip	Pji
Juvenile Gastrointestinal Polyposis	Juvenile Polyposis
Polyposis, Juvenile Intestinal	Polyposis, Familial, Of Entire Gastrointestinal Tract
Polyposis Familial Of Entire Gastrointestinal Tract	Polyposis Juvenile Intestinal
Polyposis Syndrome, Juvenile

Peripheral Vascular Disease

Peripheral Arterial Disease	Arterial Occlusive Disease
Arterial Occlusive Diseases	Pad
Peripheral Vascular Diseases	Peripheral Occlusive Disease
Peripheral Arterial Diseases	Helicobacter Infections

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome	KTS
Ktw Syndrome	Angioosteohypertrophy Syndrome
Angio-Osteohypertrophy Syndrome	Klippel Trenaunay Syndrome
Klippel-Trénaunay-Weber Syndrome	Haemangiectatic Hypertrophy
Weber-Klippel-Trenaunay	Congenital Dysplastic Angiopathy
Klippel-Trenaunay Disease	Weber Klippel Trenaunay

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05353	GDF2 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GDF2	VGNC	VGNC:29302
Mus musculus	GDF2	MGD	MGI:1321394
Macaca mulatta	GDF2	VGNC	VGNC:72909
Rattus norvegicus	GDF2	RGD	RGD:1586196
Canis familiaris	GDF2	VGNC	VGNC:41161
Others	GDF2	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)	站点地图隐私声明
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.	沪ICP备15051369号-4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

GDF2 - growth differentiation factor 2 Gene

关于 GDF2

功能概要

GDF2 基因产物(1)

GDF2 蛋白结构

重组 GDF2 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

GDF2 - growth differentiation factor 2 Gene

关于 GDF2

功能概要

GDF2 基因产物(1)

GDF2 蛋白结构

重组 GDF2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z