2. Gene
  3. VCX - variable charge X-linked Gene

VCX - variable charge X-linked Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：可变电荷 X 连锁

种属: Homo sapiens

同用名: VCX1; VCXB1; VCX-B1; VCX10R; VCX-10r

基因 ID: 26609 | 基因类型: protein coding

关于 VCX

Cytogenetic location: Xp22.31 Genomic coordinates (GRCh38): X:7,842,262-7,844,143 (from NCBI)

This gene has 5 transcripts (splice variants), 34 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 23.7).

功能概要

该基因属于 VCX/Y 基因家族，在 X 染色体和 Y 染色体上均有多个成员，全部只在雄性生殖细胞中表达。 X 连锁成员聚集在染色体 Xp22 上，Y 连锁成员是 Yq11 回文区域内该基因的两个相同拷贝。家族成员具有高度的序列同一性，除了一个 30 bp 单元在 X 连锁成员中串联重复但在 Y 连锁成员中仅出现一次。 VCX 基因簇在拷贝数方面具有多态性；不同的个体可能有不同数量的 VCX 基因。 VCX/Y 基因编码功能未知的小而高电荷的蛋白质。推定的二分核定位信号的存在表明 VCX/Y 成员是核蛋白。该基因包含 30-bp 单元的 10 个重复。[RefSeq 提供，2008 年 7 月]

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]

VCX 基因产物(2)

mRNA Protein Name
NM_001393662.1 NP_001380591.1 variable charge X-linked protein 1
NM_013452.3 NP_038480.2 variable charge X-linked protein 1
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
12862317 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12862317 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VCX 蛋白结构

VCX_VCY

VCX_VCY: Variable charge X/Y family (1 - 142)

VCX_VCY

VCX_VCY: Variable charge X/Y family (122 - 162)

VCX_VCY

VCX_VCY: Variable charge X/Y family (132 - 172)

VCX_VCY

VCX_VCY: Variable charge X/Y family (142 - 182)

VCX_VCY

VCX_VCY: Variable charge X/Y family (162 - 202)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

variable charge X-linked protein 1

variable charge protein on X with ten repeats

关联疾病

疾病名称 别名
Ichthyosis, X-Linked

X-Linked Ichthyosis

Steroid Sulfatase Deficiency

Placental Steroid Sulfatase Deficiency

Steroid Sulfatase Deficiency Disease

XLI

Sts Deficiency

Ssdd

X-Linked Recessive Ichthyosis

X-Linked Ichthyosis With Steryl-Sulphatase Deficiency

X-Linked Placental Steryl-Sulphatase Deficiency

Ssd

X Linked Ichthyosis

Recessive X-Linked Ichthyosis

Rxli

Syndromic Recessive X-Linked Ichthyosis

Recessive X-Linked Ichthyosis With Extracutaneous Manifestations

Syndromic Rxli

X-Linked Ichthyosis Syndrome

IXL

Ichthyosis X-Linked

Sex-Linked Ichthyosis

X-Linked Ichthyosis With Steryl-Sulfatase Deficiency
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Vertical Talus, Congenital

Congenital Vertical Talus

CVT

Congenital Convex Pes Valgus

Rocker-Bottom Foot Deformity

Vertical Talus

Pes Valgus, Congenital Convex

Congenital Convex Foot

Congenital Rocker-Bottom Foot

Rocker Bottom Foot

Flatfoot

Rocker-Bottom Foot

Charcot-Marie-Tooth Disease, Foot Deformity Of
Hemophagocytic Lymphohistiocytosis, Familial, 1

Familial Hemophagocytic Lymphohistiocytosis

Fhl

Familial Erythrophagocytic Lymphohistiocytosis

Hemophagocytic Syndrome

FHL1

Hplh1

Hlh1

Fel

Familial Hemophagocytic Lymphohistiocytosis 1

Primary Hemophagocytic Lymphohistiocytosis

Familial Hlh

Hlh

Familial Hemophagocytic Lymphocytosis

Hemophagocytic Lymphohistiocytosis, Familial

Reticulosis, Familial Histiocytic

Hemophagocytic Reticulosis, Familial

Erythrophagocytic Lymphohistiocytosis, Familial

Familial Histiocytic Reticulosis

Familial Hemophagocytic Histiocytosis

Familial Hemophagocytic Reticulosis

Fhlh

Hplh

Primary Hemophagocytic Hymphohistiocytosis

Genetic Hemophagocytic Lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis

Familial Hemophagocytic Lymphohistiocytosis Type 1
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15625 VCX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS15626 VCX2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS15627 VCX3A Human Pre-designed siRNA Set A Pre-designed Set / 否
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