2. Gene
  3. Robo2 - roundabout guidance receptor 2 Gene

Robo2 - roundabout guidance receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mKIAA1568; 2600013A04Rik; 9430089E08Rik; D230004I22Rik

基因 ID: 268902 | 基因类型: protein coding

关于 Robo2

功能概要

Predicted to enable identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway involved in heart induction. Acts upstream of or within axon guidance and metanephros development. Located in axolemma. Is expressed in several structures, including embryo mesenchyme; foot; jaw; nervous system; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Robo2 基因产物(6)

mRNA Protein Name
NM_001358490.1 NP_001345419.1 roundabout homolog 2 isoform 4 precursor
NM_001358491.1 NP_001345420.1 roundabout homolog 2 isoform 3
NM_001358492.1 NP_001345421.1 roundabout homolog 2 isoform 2
NM_001358493.1 NP_001345422.1 roundabout homolog 2 isoform 1
NM_001358494.1 NP_001345423.1 roundabout homolog 2 isoform 6 precursor
NM_175549.5 NP_780758.3 roundabout homolog 2 isoform 5 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aorta development IGI
IGI: 通过遗传相互作用推断
25691540 MGI
involved in aortic valve morphogenesis IGI
IGI: 通过遗传相互作用推断
25691540 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
15091338 MGI
involved in axon midline choice point recognition IGI
IGI: 通过遗传相互作用推断
18986510 MGI
involved in endocardial cushion formation IGI
IGI: 通过遗传相互作用推断
25691540 MGI
involved in heart induction IDA
IDA: 通过直接分析推断
25691540 MGI
acts upstream of or within metanephros development IMP
IMP: 通过突变表型推断
15130495 MGI
involved in olfactory bulb interneuron development IMP
IMP: 通过突变表型推断
17360927 MGI
involved in outflow tract septum morphogenesis IGI
IGI: 通过遗传相互作用推断
25691540 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
25691540 MGI
involved in pulmonary valve morphogenesis IGI
IGI: 通过遗传相互作用推断
25691540 MGI
involved in retinal ganglion cell axon guidance IMP
IMP: 通过突变表型推断
19782674 MGI
involved in synapse maturation IDA
IDA: 通过直接分析推断
34686348 MGI
involved in synapse maturation IMP
IMP: 通过突变表型推断
34686348 MGI
involved in ureteric bud development IMP
IMP: 通过突变表型推断
15130495 MGI
involved in ventricular septum morphogenesis IGI
IGI: 通过遗传相互作用推断
25691540 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axolemma IDA
IDA: 通过直接分析推断
15084255 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
34686348 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
34686348 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
34686348 MGI
is active in postsynaptic density membrane IEP
IEP: 通过表达模式推断
34686348 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

roundabout homolog 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12111 ROBO2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18841 Robo2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25333 Robo2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990763 Sifarobocept / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Robo2 NCBI NCBI:6092
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