2. Gene
  3. Nbn - nibrin Gene

Nbn - nibrin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nbs1

基因 ID: 27354 | 基因类型: protein coding

关于 Nbn

功能概要

Enables damaged DNA binding activity. Involved in blastocyst growth and isotype switching. Acts upstream of or within cell population proliferation; intracellular signal transduction; and neuromuscular process controlling balance. Located in PML body and replication fork. Colocalizes with chromosome, telomeric region. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Nijmegen breakage syndrome and T-cell acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; breast cancer; and reproductive organ Cancer (multiple). Orthologous to human NBN (nibrin). [provided by Alliance of Genome Resources, Apr 2022]

Nbn 基因产物(1)

mRNA Protein Name
NM_013752.3 NP_038780.3 nibrin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin-protein adaptor activity IDA
IDA: 通过直接分析推断
28216226 MGI
enables damaged DNA binding IDA
IDA: 通过直接分析推断
11934988 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17429352 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in blastocyst growth IMP
IMP: 通过突变表型推断
14612522 MGI
involved in double-strand break repair via alternative nonhomologous end joining IDA
IDA: 通过直接分析推断
28216226 MGI
involved in in utero embryonic development IMP
IMP: 通过突变表型推断
14612522 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
18614044 MGI
involved in isotype switching IDA
IDA: 通过直接分析推断
15668383 MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
18614044 MGI
acts upstream of or within neuroblast proliferation IMP
IMP: 通过突变表型推断
15821748 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: 通过突变表型推断
15821748 MGI
involved in protection from non-homologous end joining at telomere IDA
IDA: 通过直接分析推断
28216226 MGI
involved in telomere maintenance in response to DNA damage IDA
IDA: 通过直接分析推断
28216226 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Mre11 complex IDA
IDA: 通过直接分析推断
18854157 MGI
located in PML body IDA
IDA: 通过直接分析推断
23444137 MGI
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
23444137 MGI
is active in chromosome, telomeric region IDA
IDA: 通过直接分析推断
28216226 MGI
located in chromosome, telomeric region IDA
IDA: 通过直接分析推断
10811102 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11555636 MGI
located in replication fork IDA
IDA: 通过直接分析推断
11934988 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nibrin

cell cycle regulatory protein p95

nijmegen breakage syndrome protein 1 homolog

Nbn 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nbn Q9R207 Mre11 Mus musculus Q61216
Anti Bait CoIP
17429352
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09057 NBN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01048 ARTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18740 Nbn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25227 Nbn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nbn NCBI NCBI:4683
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