1. Gene
  2. Pik3c2b - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta Gene

Pik3c2b - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta Gene

中文名称:磷脂酰肌醇 4-磷酸 3-激酶,催化亚基 2 型

种属: Rattus norvegicus

基因 ID: 289021 | 基因类型: protein coding

关于 Pik3c2b

Primary_assembly 13: 44,495,050-44,555,612 forward strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 207 orthologues, 9 paralogues and is associated with 4 phenotypes. Biased expression in Heart (RPKM 69.9), Muscle (RPKM 58.1) and 9 other tissues.

功能概要

预测该基因编码的蛋白具有 1-phosphatidylinositol-3-kinase 活性; 1-磷脂酰肌醇-4-磷酸 3-激酶活性;和脂质激酶活性。预计参与细胞迁移;磷脂酰肌醇 3-激酶信号;和磷脂酰肌醇-3-磷酸生物合成过程。预测作用于自噬体组织的上游或内部;细胞对饥饿的反应;和蛋白激酶 B 信号。预测位于胞质溶胶中;内吞囊泡;和核质。预计是磷脂酰肌醇 3-激酶复合物的一部分。预计在细胞质和质膜中有活性。与人 PIK3C2B(磷脂酰肌醇 4 磷酸 3 激酶催化亚基 2 型 beta)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; and lipid kinase activity. Predicted to be involved in cell migration; phosphatidylinositol 3-kinase signaling; and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and protein kinase B signaling. Predicted to be located in cytosol; endocytic vesicle; and nucleoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2b 基因产物(1)

mRNA Protein Name
NM_001105951.1 NP_001099421.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Pik3c2b 蛋白结构

PI3K_rbd

PI3K_rbd: pfam00794 (362 - 464)

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (620 - 792)

PI3Ka_II

PI3Ka_II: cd00869 (811 - 979)

PI3Kc_C2_beta

PI3Kc_C2_beta: cd00895 (985 - 1338)

PX_PI3K_C2_beta

PX_PI3K_C2_beta: cd07290 (1367 - 1475)

C2B_PI3K_class_II

C2B_PI3K_class_II: cd08381 (1503 - 1625)

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蛋白主名 其他名称

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

nuclear cap binding protein subunit 2

phosphoinositide-3-kinase, class 2, beta polypeptide

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pik3c2b NCBI NCBI:5287