RGCC - regulator of cell cycle Gene

中文名称：细胞周期调节因子

种属: Homo sapiens

同用名: RGC32; RGC-32; C13orf15; bA157L14.2

关于 RGCC

功能概要

该基因被认为可以调节细胞周期进程。它由 p53 响应 DNA 损伤，或由导致细胞周期激活的补体系统蛋白的亚裂解水平诱导。编码的蛋白质在间期定位于细胞质，在有丝分裂期间定位于中心体。该蛋白与 polo 样激酶 1 形成复合物。该蛋白还易位至细胞核以响应补体系统蛋白的处理，并且可以与细胞分裂周期 2 蛋白相关并增加其激酶活性。在不同的测定和细胞类型中，这种蛋白质的过表达已被证明可以激活或抑制细胞周期进程。[RefSeq 提供，2008 年 7 月]

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of Complement System proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during Mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with Complement System proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]